G-protein-coupled receptors: the new dopamine receptor subtypes

David K. Grandy; Olivier Civelli

doi:10.1016/0959-4388(92)90115-2

G-protein-coupled receptors: the new dopamine receptor subtypes

David K. Grandy, Olivier Civelli

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The family of genes encoding G-protein-coupled dopamine receptors continues to grow with the recent cloning of a fifth member. The availability of these clones has revolutionized the dopamine receptor field. Expression of individual dopamine receptors is permitting the detailed analysis of their pharmacology and coupling to second messenger systems, while probes based on the receptors' nucleotide sequences are being used to gain new insights into their tissue distribution and genetics.

Original language	English (US)
Pages (from-to)	275-281
Number of pages	7
Journal	Current Opinion in Neurobiology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/0959-4388(92)90115-2
State	Published - Jun 1992

ASJC Scopus subject areas

General Neuroscience

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10.1016/0959-4388(92)90115-2

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title = "G-protein-coupled receptors: the new dopamine receptor subtypes",

abstract = "The family of genes encoding G-protein-coupled dopamine receptors continues to grow with the recent cloning of a fifth member. The availability of these clones has revolutionized the dopamine receptor field. Expression of individual dopamine receptors is permitting the detailed analysis of their pharmacology and coupling to second messenger systems, while probes based on the receptors' nucleotide sequences are being used to gain new insights into their tissue distribution and genetics.",

author = "Grandy, {David K.} and Olivier Civelli",

note = "Funding Information: We would like to thank our colleagues SJ Watson, J Meador-Woodruff, J Eubanks and J Gelemter for making unpublished results available to us. We would also Like to thank J Shiigl for preparing the illustration. The work presented from our laboratoty was supported in part by grants from the Supreme Council of the Scottish Rite (D Grandy, 0 Civelli) and National Institute of Health MH45614( 0 Civelli).",

year = "1992",

month = jun,

doi = "10.1016/0959-4388(92)90115-2",

language = "English (US)",

volume = "2",

pages = "275--281",

journal = "Current Opinion in Neurobiology",

issn = "0959-4388",

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T1 - G-protein-coupled receptors

T2 - the new dopamine receptor subtypes

AU - Grandy, David K.

AU - Civelli, Olivier

N1 - Funding Information: We would like to thank our colleagues SJ Watson, J Meador-Woodruff, J Eubanks and J Gelemter for making unpublished results available to us. We would also Like to thank J Shiigl for preparing the illustration. The work presented from our laboratoty was supported in part by grants from the Supreme Council of the Scottish Rite (D Grandy, 0 Civelli) and National Institute of Health MH45614( 0 Civelli).

PY - 1992/6

Y1 - 1992/6

N2 - The family of genes encoding G-protein-coupled dopamine receptors continues to grow with the recent cloning of a fifth member. The availability of these clones has revolutionized the dopamine receptor field. Expression of individual dopamine receptors is permitting the detailed analysis of their pharmacology and coupling to second messenger systems, while probes based on the receptors' nucleotide sequences are being used to gain new insights into their tissue distribution and genetics.

AB - The family of genes encoding G-protein-coupled dopamine receptors continues to grow with the recent cloning of a fifth member. The availability of these clones has revolutionized the dopamine receptor field. Expression of individual dopamine receptors is permitting the detailed analysis of their pharmacology and coupling to second messenger systems, while probes based on the receptors' nucleotide sequences are being used to gain new insights into their tissue distribution and genetics.

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G-protein-coupled receptors: the new dopamine receptor subtypes

Abstract

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