Abstract
The growth-inhibiting peptide hormone somatostatin stimulates phosphotyrosine phosphatase activity in the human pancreatic cell line MIA PaCa-2. This hormonal activation was mediated by a pertussis toxin-sensitive guanosine 5′-triphosphate-binding protein (G protein) in the membranes of these cells. Activation of this G protein by somatostatin stimulated the dephosphorylation of exogenous epidermal growth factor receptor prepared from A-431 cells in vitro. This pathway may mediate the antineoplastic action of somatostatin in these cells and in human tumors and could represent a general mechanism of G protein coupling that is utilized by normal cells in the hormonal control of cell growth.
Original language | English (US) |
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Pages (from-to) | 1215-1217 |
Number of pages | 3 |
Journal | Science |
Volume | 256 |
Issue number | 5060 |
DOIs | |
State | Published - 1992 |
ASJC Scopus subject areas
- General