G protein activation of a hormone-stimulated phosphatase in human tumor cells

Ming Gui Pan, Tullio Florio, Philip J.S. Stork

Research output: Contribution to journalArticle

187 Scopus citations

Abstract

The growth-inhibiting peptide hormone somatostatin stimulates phosphotyrosine phosphatase activity in the human pancreatic cell line MIA PaCa-2. This hormonal activation was mediated by a pertussis toxin-sensitive guanosine 5′-triphosphate-binding protein (G protein) in the membranes of these cells. Activation of this G protein by somatostatin stimulated the dephosphorylation of exogenous epidermal growth factor receptor prepared from A-431 cells in vitro. This pathway may mediate the antineoplastic action of somatostatin in these cells and in human tumors and could represent a general mechanism of G protein coupling that is utilized by normal cells in the hormonal control of cell growth.

Original languageEnglish (US)
Pages (from-to)1215-1217
Number of pages3
JournalScience
Volume256
Issue number5060
DOIs
StatePublished - Jan 1 1992

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