Future Directions for Hypothermia following Severe Traumatic Brian Injury

Annie W. Chiu, Holly Hinson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Traumatic brain injury (TBI) is a serious health care problem on both individual and public health levels. As a major cause of death and disability in the United States, it is associated with a significant economic and public health burden. Although the evidence to support the use of induced hypothermia on neurologic outcome after cardiac arrest is well established, its use in treating TBI remains controversial. Hypothermia has the potential to mitigate some of the destructive processes that occur as part of secondary brain injury after TBI. Hypothermia can be helpful in lowering intracranial pressure, for example, but its influence on functional outcome is unclear. There is insufficient evidence to support the broad use of prophylactic hypothermia for neuroprotection after TBI. Investigators are beginning to more carefully select patients for temperature modulating therapies, in a more personalized approach. Examples include targeting immunomodulation and scaling hypothermia to achieve metabolic targets. This review will summarize the clinical evidence for the use of hypothermia to limit secondary brain injury following acute TBI.

Original languageEnglish (US)
Pages (from-to)768-774
Number of pages7
JournalSeminars in Respiratory and Critical Care Medicine
Volume38
Issue number6
DOIs
StatePublished - Dec 1 2017

Fingerprint

Hypothermia
Brain Injuries
Wounds and Injuries
Public Health
Induced Hypothermia
Immunomodulation
Intracranial Pressure
Heart Arrest
Nervous System
Cause of Death
Economics
Research Personnel
Traumatic Brain Injury
Direction compound
Delivery of Health Care
Temperature
Therapeutics

Keywords

  • cooling
  • fever
  • Hypothermia
  • intracranial pressure
  • traumatic brain injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Future Directions for Hypothermia following Severe Traumatic Brian Injury. / Chiu, Annie W.; Hinson, Holly.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 38, No. 6, 01.12.2017, p. 768-774.

Research output: Contribution to journalArticle

@article{67baa61957bd42f386f1f1cd0f987c05,
title = "Future Directions for Hypothermia following Severe Traumatic Brian Injury",
abstract = "Traumatic brain injury (TBI) is a serious health care problem on both individual and public health levels. As a major cause of death and disability in the United States, it is associated with a significant economic and public health burden. Although the evidence to support the use of induced hypothermia on neurologic outcome after cardiac arrest is well established, its use in treating TBI remains controversial. Hypothermia has the potential to mitigate some of the destructive processes that occur as part of secondary brain injury after TBI. Hypothermia can be helpful in lowering intracranial pressure, for example, but its influence on functional outcome is unclear. There is insufficient evidence to support the broad use of prophylactic hypothermia for neuroprotection after TBI. Investigators are beginning to more carefully select patients for temperature modulating therapies, in a more personalized approach. Examples include targeting immunomodulation and scaling hypothermia to achieve metabolic targets. This review will summarize the clinical evidence for the use of hypothermia to limit secondary brain injury following acute TBI.",
keywords = "cooling, fever, Hypothermia, intracranial pressure, traumatic brain injury",
author = "Chiu, {Annie W.} and Holly Hinson",
year = "2017",
month = "12",
day = "1",
doi = "10.1055/s-0037-1607989",
language = "English (US)",
volume = "38",
pages = "768--774",
journal = "Seminars in Respiratory and Critical Care Medicine",
issn = "1069-3424",
publisher = "Thieme Medical Publishers",
number = "6",

}

TY - JOUR

T1 - Future Directions for Hypothermia following Severe Traumatic Brian Injury

AU - Chiu, Annie W.

AU - Hinson, Holly

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Traumatic brain injury (TBI) is a serious health care problem on both individual and public health levels. As a major cause of death and disability in the United States, it is associated with a significant economic and public health burden. Although the evidence to support the use of induced hypothermia on neurologic outcome after cardiac arrest is well established, its use in treating TBI remains controversial. Hypothermia has the potential to mitigate some of the destructive processes that occur as part of secondary brain injury after TBI. Hypothermia can be helpful in lowering intracranial pressure, for example, but its influence on functional outcome is unclear. There is insufficient evidence to support the broad use of prophylactic hypothermia for neuroprotection after TBI. Investigators are beginning to more carefully select patients for temperature modulating therapies, in a more personalized approach. Examples include targeting immunomodulation and scaling hypothermia to achieve metabolic targets. This review will summarize the clinical evidence for the use of hypothermia to limit secondary brain injury following acute TBI.

AB - Traumatic brain injury (TBI) is a serious health care problem on both individual and public health levels. As a major cause of death and disability in the United States, it is associated with a significant economic and public health burden. Although the evidence to support the use of induced hypothermia on neurologic outcome after cardiac arrest is well established, its use in treating TBI remains controversial. Hypothermia has the potential to mitigate some of the destructive processes that occur as part of secondary brain injury after TBI. Hypothermia can be helpful in lowering intracranial pressure, for example, but its influence on functional outcome is unclear. There is insufficient evidence to support the broad use of prophylactic hypothermia for neuroprotection after TBI. Investigators are beginning to more carefully select patients for temperature modulating therapies, in a more personalized approach. Examples include targeting immunomodulation and scaling hypothermia to achieve metabolic targets. This review will summarize the clinical evidence for the use of hypothermia to limit secondary brain injury following acute TBI.

KW - cooling

KW - fever

KW - Hypothermia

KW - intracranial pressure

KW - traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=85038638845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038638845&partnerID=8YFLogxK

U2 - 10.1055/s-0037-1607989

DO - 10.1055/s-0037-1607989

M3 - Article

VL - 38

SP - 768

EP - 774

JO - Seminars in Respiratory and Critical Care Medicine

JF - Seminars in Respiratory and Critical Care Medicine

SN - 1069-3424

IS - 6

ER -