Furosemide pharmacokinetics following intratracheal instillation in the guinea pig

S. A. Smith, D. A.M. Pillers, J. T. Gilhooly, M. A. Wall, G. D. Olsen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Inhaled furosemide has been shown to attenuate bronchospasm in asthmatics and to increase lung compliance in infants with bronchopulmonary dysplasia (BPD). The reports involving BPD used a dose of 1 mg/kg and some have failed to show an effect with that dose. We determined the pharmacokinetics of furosemide administered directly to the airway in 7 young adult male guinea pigs who received intravenous and intratracheal doses of furosemide. Each animal received a 3 mg/kg i.v. bolus, 1, 3 and 6 mg/kg i.t. in 2 ml/kg normal saline and 3 mg/kg i.t. in 2 ml/kg bovine extract surfactant. Blood was sampled multiple times after each dose. The mean fraction of the intratracheal dose absorbed was 0.50-0.60 for all doses. Surfactant delayed the absorption of furosemide but did not alter the fraction absorbed.

Original languageEnglish (US)
Pages (from-to)191-199
Number of pages9
JournalBiology of the Neonate
Volume68
Issue number3
StatePublished - Jan 1 1995

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Keywords

  • Furosemide, inhaled
  • Guinea pig
  • Intratracheal instillation
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Cite this

Smith, S. A., Pillers, D. A. M., Gilhooly, J. T., Wall, M. A., & Olsen, G. D. (1995). Furosemide pharmacokinetics following intratracheal instillation in the guinea pig. Biology of the Neonate, 68(3), 191-199.