Fundus autofluorescence changes in cytomegalovirus retinitis

Steven Yeh, Farzin Forooghian, Lisa J. Faia, Eric D. Weichel, Wai T. Wong, Hatice N. Sen, Brian T. Chan-Kai, Scott R. Witherspoon, Andreas (Andy) Lauer, Emily Y. Chew, Robert B. Nussenblatt

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to describe fundus autofluorescence imaging features of cytomegalovirus (CMV) retinitis and to correlate fundus autofluorescence features with clinical activity. Methods: A retrospective case series was undertaken to evaluate nine eyes of six patients with active CMV retinitis. Patients were evaluated with a comprehensive ophthalmic examination, fundus autofluorescence imaging, and fundus photography. Oral valganciclovir, intravitreal ganciclovir, intravitreal foscarnet, or an ganciclovir implant was administered as clinically indicated. Results: In all nine eyes with active CMV retinitis, a hyperautofluorescent signal on fundus autofluorescence imaging was correlated spatially with the border of advancing CMV retinitis. Stippled areas of alternating hyperautofluorescence and hypoautofluorescence were observed in regions of retinal pigment epithelium atrophy from prior CMV retinitis. In three eyes with subtle CMV reactivation, a hyperautofluorescent border was helpful in the detection and localization of active CMV retinitis. In another patient, diffuse, punctate hyperautofluorescence after intravitreal ganciclovir and foscarnet was a concern for medication-related toxicity. Conclusion: Fundus autofluorescence imaging was valuable in highlighting areas of active CMV retinitis in all patients in this series, including two patients with subtle clinical features. Fundus autofluorescence may be useful as an adjunctive imaging modality for the detection of CMV activity and aid in our understanding of the structural changes during episodes of CMV retinitis.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalRetina
Volume30
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Cytomegalovirus Retinitis
Optical Imaging
Ganciclovir
Foscarnet
Cytomegalovirus
Retinal Pigment Epithelium
Photography
Atrophy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Yeh, S., Forooghian, F., Faia, L. J., Weichel, E. D., Wong, W. T., Sen, H. N., ... Nussenblatt, R. B. (2010). Fundus autofluorescence changes in cytomegalovirus retinitis. Retina, 30(1), 42-50. https://doi.org/10.1097/IAE.0b013e3181bfbdb2

Fundus autofluorescence changes in cytomegalovirus retinitis. / Yeh, Steven; Forooghian, Farzin; Faia, Lisa J.; Weichel, Eric D.; Wong, Wai T.; Sen, Hatice N.; Chan-Kai, Brian T.; Witherspoon, Scott R.; Lauer, Andreas (Andy); Chew, Emily Y.; Nussenblatt, Robert B.

In: Retina, Vol. 30, No. 1, 01.2010, p. 42-50.

Research output: Contribution to journalArticle

Yeh, S, Forooghian, F, Faia, LJ, Weichel, ED, Wong, WT, Sen, HN, Chan-Kai, BT, Witherspoon, SR, Lauer, AA, Chew, EY & Nussenblatt, RB 2010, 'Fundus autofluorescence changes in cytomegalovirus retinitis', Retina, vol. 30, no. 1, pp. 42-50. https://doi.org/10.1097/IAE.0b013e3181bfbdb2
Yeh S, Forooghian F, Faia LJ, Weichel ED, Wong WT, Sen HN et al. Fundus autofluorescence changes in cytomegalovirus retinitis. Retina. 2010 Jan;30(1):42-50. https://doi.org/10.1097/IAE.0b013e3181bfbdb2
Yeh, Steven ; Forooghian, Farzin ; Faia, Lisa J. ; Weichel, Eric D. ; Wong, Wai T. ; Sen, Hatice N. ; Chan-Kai, Brian T. ; Witherspoon, Scott R. ; Lauer, Andreas (Andy) ; Chew, Emily Y. ; Nussenblatt, Robert B. / Fundus autofluorescence changes in cytomegalovirus retinitis. In: Retina. 2010 ; Vol. 30, No. 1. pp. 42-50.
@article{1a88b09bc573490797b3b1ee3a688a3b,
title = "Fundus autofluorescence changes in cytomegalovirus retinitis",
abstract = "Purpose: The purpose of this study was to describe fundus autofluorescence imaging features of cytomegalovirus (CMV) retinitis and to correlate fundus autofluorescence features with clinical activity. Methods: A retrospective case series was undertaken to evaluate nine eyes of six patients with active CMV retinitis. Patients were evaluated with a comprehensive ophthalmic examination, fundus autofluorescence imaging, and fundus photography. Oral valganciclovir, intravitreal ganciclovir, intravitreal foscarnet, or an ganciclovir implant was administered as clinically indicated. Results: In all nine eyes with active CMV retinitis, a hyperautofluorescent signal on fundus autofluorescence imaging was correlated spatially with the border of advancing CMV retinitis. Stippled areas of alternating hyperautofluorescence and hypoautofluorescence were observed in regions of retinal pigment epithelium atrophy from prior CMV retinitis. In three eyes with subtle CMV reactivation, a hyperautofluorescent border was helpful in the detection and localization of active CMV retinitis. In another patient, diffuse, punctate hyperautofluorescence after intravitreal ganciclovir and foscarnet was a concern for medication-related toxicity. Conclusion: Fundus autofluorescence imaging was valuable in highlighting areas of active CMV retinitis in all patients in this series, including two patients with subtle clinical features. Fundus autofluorescence may be useful as an adjunctive imaging modality for the detection of CMV activity and aid in our understanding of the structural changes during episodes of CMV retinitis.",
author = "Steven Yeh and Farzin Forooghian and Faia, {Lisa J.} and Weichel, {Eric D.} and Wong, {Wai T.} and Sen, {Hatice N.} and Chan-Kai, {Brian T.} and Witherspoon, {Scott R.} and Lauer, {Andreas (Andy)} and Chew, {Emily Y.} and Nussenblatt, {Robert B.}",
year = "2010",
month = "1",
doi = "10.1097/IAE.0b013e3181bfbdb2",
language = "English (US)",
volume = "30",
pages = "42--50",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Fundus autofluorescence changes in cytomegalovirus retinitis

AU - Yeh, Steven

AU - Forooghian, Farzin

AU - Faia, Lisa J.

AU - Weichel, Eric D.

AU - Wong, Wai T.

AU - Sen, Hatice N.

AU - Chan-Kai, Brian T.

AU - Witherspoon, Scott R.

AU - Lauer, Andreas (Andy)

AU - Chew, Emily Y.

AU - Nussenblatt, Robert B.

PY - 2010/1

Y1 - 2010/1

N2 - Purpose: The purpose of this study was to describe fundus autofluorescence imaging features of cytomegalovirus (CMV) retinitis and to correlate fundus autofluorescence features with clinical activity. Methods: A retrospective case series was undertaken to evaluate nine eyes of six patients with active CMV retinitis. Patients were evaluated with a comprehensive ophthalmic examination, fundus autofluorescence imaging, and fundus photography. Oral valganciclovir, intravitreal ganciclovir, intravitreal foscarnet, or an ganciclovir implant was administered as clinically indicated. Results: In all nine eyes with active CMV retinitis, a hyperautofluorescent signal on fundus autofluorescence imaging was correlated spatially with the border of advancing CMV retinitis. Stippled areas of alternating hyperautofluorescence and hypoautofluorescence were observed in regions of retinal pigment epithelium atrophy from prior CMV retinitis. In three eyes with subtle CMV reactivation, a hyperautofluorescent border was helpful in the detection and localization of active CMV retinitis. In another patient, diffuse, punctate hyperautofluorescence after intravitreal ganciclovir and foscarnet was a concern for medication-related toxicity. Conclusion: Fundus autofluorescence imaging was valuable in highlighting areas of active CMV retinitis in all patients in this series, including two patients with subtle clinical features. Fundus autofluorescence may be useful as an adjunctive imaging modality for the detection of CMV activity and aid in our understanding of the structural changes during episodes of CMV retinitis.

AB - Purpose: The purpose of this study was to describe fundus autofluorescence imaging features of cytomegalovirus (CMV) retinitis and to correlate fundus autofluorescence features with clinical activity. Methods: A retrospective case series was undertaken to evaluate nine eyes of six patients with active CMV retinitis. Patients were evaluated with a comprehensive ophthalmic examination, fundus autofluorescence imaging, and fundus photography. Oral valganciclovir, intravitreal ganciclovir, intravitreal foscarnet, or an ganciclovir implant was administered as clinically indicated. Results: In all nine eyes with active CMV retinitis, a hyperautofluorescent signal on fundus autofluorescence imaging was correlated spatially with the border of advancing CMV retinitis. Stippled areas of alternating hyperautofluorescence and hypoautofluorescence were observed in regions of retinal pigment epithelium atrophy from prior CMV retinitis. In three eyes with subtle CMV reactivation, a hyperautofluorescent border was helpful in the detection and localization of active CMV retinitis. In another patient, diffuse, punctate hyperautofluorescence after intravitreal ganciclovir and foscarnet was a concern for medication-related toxicity. Conclusion: Fundus autofluorescence imaging was valuable in highlighting areas of active CMV retinitis in all patients in this series, including two patients with subtle clinical features. Fundus autofluorescence may be useful as an adjunctive imaging modality for the detection of CMV activity and aid in our understanding of the structural changes during episodes of CMV retinitis.

UR - http://www.scopus.com/inward/record.url?scp=75149114172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75149114172&partnerID=8YFLogxK

U2 - 10.1097/IAE.0b013e3181bfbdb2

DO - 10.1097/IAE.0b013e3181bfbdb2

M3 - Article

VL - 30

SP - 42

EP - 50

JO - Retina

JF - Retina

SN - 0275-004X

IS - 1

ER -