Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Catherine S. Grasso, Yujie Tang, Nathalene Truffaux, Noah E. Berlow, Lining Liu, Marie Anne Debily, Michael J. Quist, Lara Davis, Elaine C. Huang, Pamelyn J. Woo, Anitha Ponnuswami, Spenser Chen, Tessa B. Johung, Wenchao Sun, Mari Kogiso, Yuchen Du, Lin Qi, Yulun Huang, Marianne Hütt-Cabezas, Katherine E. WarrenLudivine Le Dret, Paul S. Meltzer, Hua Mao, Martha Quezado, Dannis G. Van Vuurden, Jinu Abraham, Maryam Fouladi, Matthew N. Svalina, Nicholas Wang, Cynthia Hawkins, Javad Nazarian, Marta M. Alonso, Eric H. Raabe, Esther Hulleman, Paul Spellman, Xiao Nan Li, Charles Keller, Ranadip Pal, Jacques Grill, Michelle Monje

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalNature Medicine
Volume21
Issue number6
DOIs
StatePublished - May 4 2015

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Glioma
Histone Demethylases
Histone Deacetylase Inhibitors
Heterografts
RNA
Testing
Therapeutics
panobinostat
Neoplasms
GSK-J4

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Grasso, C. S., Tang, Y., Truffaux, N., Berlow, N. E., Liu, L., Debily, M. A., ... Monje, M. (2015). Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nature Medicine, 21(6), 555-559. https://doi.org/10.1038/nm.3855

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. / Grasso, Catherine S.; Tang, Yujie; Truffaux, Nathalene; Berlow, Noah E.; Liu, Lining; Debily, Marie Anne; Quist, Michael J.; Davis, Lara; Huang, Elaine C.; Woo, Pamelyn J.; Ponnuswami, Anitha; Chen, Spenser; Johung, Tessa B.; Sun, Wenchao; Kogiso, Mari; Du, Yuchen; Qi, Lin; Huang, Yulun; Hütt-Cabezas, Marianne; Warren, Katherine E.; Le Dret, Ludivine; Meltzer, Paul S.; Mao, Hua; Quezado, Martha; Van Vuurden, Dannis G.; Abraham, Jinu; Fouladi, Maryam; Svalina, Matthew N.; Wang, Nicholas; Hawkins, Cynthia; Nazarian, Javad; Alonso, Marta M.; Raabe, Eric H.; Hulleman, Esther; Spellman, Paul; Li, Xiao Nan; Keller, Charles; Pal, Ranadip; Grill, Jacques; Monje, Michelle.

In: Nature Medicine, Vol. 21, No. 6, 04.05.2015, p. 555-559.

Research output: Contribution to journalArticle

Grasso, CS, Tang, Y, Truffaux, N, Berlow, NE, Liu, L, Debily, MA, Quist, MJ, Davis, L, Huang, EC, Woo, PJ, Ponnuswami, A, Chen, S, Johung, TB, Sun, W, Kogiso, M, Du, Y, Qi, L, Huang, Y, Hütt-Cabezas, M, Warren, KE, Le Dret, L, Meltzer, PS, Mao, H, Quezado, M, Van Vuurden, DG, Abraham, J, Fouladi, M, Svalina, MN, Wang, N, Hawkins, C, Nazarian, J, Alonso, MM, Raabe, EH, Hulleman, E, Spellman, P, Li, XN, Keller, C, Pal, R, Grill, J & Monje, M 2015, 'Functionally defined therapeutic targets in diffuse intrinsic pontine glioma', Nature Medicine, vol. 21, no. 6, pp. 555-559. https://doi.org/10.1038/nm.3855
Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA et al. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nature Medicine. 2015 May 4;21(6):555-559. https://doi.org/10.1038/nm.3855
Grasso, Catherine S. ; Tang, Yujie ; Truffaux, Nathalene ; Berlow, Noah E. ; Liu, Lining ; Debily, Marie Anne ; Quist, Michael J. ; Davis, Lara ; Huang, Elaine C. ; Woo, Pamelyn J. ; Ponnuswami, Anitha ; Chen, Spenser ; Johung, Tessa B. ; Sun, Wenchao ; Kogiso, Mari ; Du, Yuchen ; Qi, Lin ; Huang, Yulun ; Hütt-Cabezas, Marianne ; Warren, Katherine E. ; Le Dret, Ludivine ; Meltzer, Paul S. ; Mao, Hua ; Quezado, Martha ; Van Vuurden, Dannis G. ; Abraham, Jinu ; Fouladi, Maryam ; Svalina, Matthew N. ; Wang, Nicholas ; Hawkins, Cynthia ; Nazarian, Javad ; Alonso, Marta M. ; Raabe, Eric H. ; Hulleman, Esther ; Spellman, Paul ; Li, Xiao Nan ; Keller, Charles ; Pal, Ranadip ; Grill, Jacques ; Monje, Michelle. / Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. In: Nature Medicine. 2015 ; Vol. 21, No. 6. pp. 555-559.
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