Functionalized nanoporous silica for the removal of heavy metals from biological systems: Adsorption and application

Wassana Yantasee, Ryan D. Rutledge, Wilaiwan Chouyyok, Vichaya Sukwarotwat, Galya Orr, Cynthia L. Warner, Marvin G. Warner, Glen E. Fryxell, Robert J. Wiacek, Charles Timchalk, R. Shane Addleman

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Surface-functionalized nanoporous silica, often referred to as self-assembled monolayers on mesoporous supports (SAMMS), has previously demonstrated the ability to serve as very effective heavy metal sorbents in a range of aquatic and environmental systems, suggesting that they may be advantageously utilized for biomedical applications such as chelation therapy. Herein we evaluate surface chemistries for heavy metal capture from biological fluids, various facets of the materials' biocompatibility, and the suitability of these materials as potential therapeutics. Of the materials tested, thiol-functionalized SAMMS proved most capable of removing selected heavy metals from biological solutions (i.e., blood, urine, etc.) Consequentially, thiol-functionalized SAMMS was further analyzed to assess the material's performance under a number of different biologically relevant conditions (i.e., variable pH and ionic strength) to gauge any potentially negative effects resulting from interaction with the sorbent, such as cellular toxicity or the removal of essential minerals. Additionally, cellular uptake studies demonstrated no cell membrane permeation by the silica-based materials generally highlighting their ability to remain cellularly inert and thus nontoxic. The results show that organic ligand functionalized nanoporous silica could be a valuable material for a range of detoxification therapies and potentially other biomedical applications.

Original languageEnglish (US)
Pages (from-to)2749-2758
Number of pages10
JournalACS Applied Materials and Interfaces
Volume2
Issue number10
DOIs
StatePublished - Oct 27 2010

Keywords

  • SAMMS
  • biocompatibility
  • detoxification
  • heavy-metal chelation
  • iminodiacetic acid
  • ion exchange
  • mesoporous
  • nanoporous
  • sorbent
  • thiol

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'Functionalized nanoporous silica for the removal of heavy metals from biological systems: Adsorption and application'. Together they form a unique fingerprint.

  • Cite this

    Yantasee, W., Rutledge, R. D., Chouyyok, W., Sukwarotwat, V., Orr, G., Warner, C. L., Warner, M. G., Fryxell, G. E., Wiacek, R. J., Timchalk, C., & Addleman, R. S. (2010). Functionalized nanoporous silica for the removal of heavy metals from biological systems: Adsorption and application. ACS Applied Materials and Interfaces, 2(10), 2749-2758. https://doi.org/10.1021/am100616b