Functional outcomes following ankle arthrodesis in males with haemophilia: analyses using the CDC's Universal Data Collection surveillance project

Universal Data Collection Joint Outcome Working Group, Hemophilia Treatment Center Network Study Investigators

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In persons with haemophilia (PWH), repeated ankle haemarthroses lead to pain, loss of joint range of motion (ROM), and limitations in activity and participation in society. PWH are offered ankle arthrodesis (AA) to eliminate pain. In our experience, PWH are hesitant to proceed to AA due to concerns regarding gait anomalies, functional decline and complete loss of ROM. The aim of this study was to report outcomes in ROM, assistive device (AD)/wheelchair use, activity scale and work/school absenteeism for participants in the CDC's Universal Data Collection surveillance project (UDC) pre- and post- AA. Males with haemophilia enrolled in the UDC with first report of AA (1998-2010) were selected. Descriptive statistics were calculated using data from the annual study visit pre-AA and the follow-up visit (~12-24 months) post-AA. The 68 subjects who fulfilled the criteria were: mean age 36.9 years (SD = 12.9); 85.3% white; 85.3% haemophilia A; 72% severe, 20.6% moderate; and 10.3% with inhibitor once during the study period. Mean loss in total arc of ankle motion was 17.02° (SD = 21.8, P ≤ 0.01) pre- compared to post-AA. For 61.8%, there was no change in use of AD for ambulation/mobility. For 85.3%, there was no change in use of a wheelchair. On a self-reported activity scale, 11.8% improved, 8.8% worsened and 79.4% did not change. Work/school absenteeism averaged 2.7 (SD = 6.4) pre- and 1.5 (SD = 6.4, P = 0.26) days per year post-AA. While ankle ROM was significantly reduced post-AA, for most subjects, there was no change in use of AD/wheelchair for ambulation/mobility. Physical activity was maintained and work/school absenteeism remained stable.

Original languageEnglish (US)
Pages (from-to)709-715
Number of pages7
JournalHaemophilia : the official journal of the World Federation of Hemophilia
Volume20
Issue number5
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Fingerprint

Arthrodesis
Hemophilia A
Centers for Disease Control and Prevention (U.S.)
Ankle
Articular Range of Motion
Self-Help Devices
Absenteeism
Wheelchairs
Walking
Hemarthrosis
Pain
Gait

Keywords

  • ankle arthrodesis
  • ankle fusion
  • arthropathy
  • haemophilia
  • outcomes
  • range of motion

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

Cite this

Functional outcomes following ankle arthrodesis in males with haemophilia : analyses using the CDC's Universal Data Collection surveillance project. / Universal Data Collection Joint Outcome Working Group; Hemophilia Treatment Center Network Study Investigators.

In: Haemophilia : the official journal of the World Federation of Hemophilia, Vol. 20, No. 5, 01.09.2014, p. 709-715.

Research output: Contribution to journalArticle

Universal Data Collection Joint Outcome Working Group ; Hemophilia Treatment Center Network Study Investigators. / Functional outcomes following ankle arthrodesis in males with haemophilia : analyses using the CDC's Universal Data Collection surveillance project. In: Haemophilia : the official journal of the World Federation of Hemophilia. 2014 ; Vol. 20, No. 5. pp. 709-715.
@article{e37b27670c39418caae15470c0417305,
title = "Functional outcomes following ankle arthrodesis in males with haemophilia: analyses using the CDC's Universal Data Collection surveillance project",
abstract = "In persons with haemophilia (PWH), repeated ankle haemarthroses lead to pain, loss of joint range of motion (ROM), and limitations in activity and participation in society. PWH are offered ankle arthrodesis (AA) to eliminate pain. In our experience, PWH are hesitant to proceed to AA due to concerns regarding gait anomalies, functional decline and complete loss of ROM. The aim of this study was to report outcomes in ROM, assistive device (AD)/wheelchair use, activity scale and work/school absenteeism for participants in the CDC's Universal Data Collection surveillance project (UDC) pre- and post- AA. Males with haemophilia enrolled in the UDC with first report of AA (1998-2010) were selected. Descriptive statistics were calculated using data from the annual study visit pre-AA and the follow-up visit (~12-24 months) post-AA. The 68 subjects who fulfilled the criteria were: mean age 36.9 years (SD = 12.9); 85.3{\%} white; 85.3{\%} haemophilia A; 72{\%} severe, 20.6{\%} moderate; and 10.3{\%} with inhibitor once during the study period. Mean loss in total arc of ankle motion was 17.02° (SD = 21.8, P ≤ 0.01) pre- compared to post-AA. For 61.8{\%}, there was no change in use of AD for ambulation/mobility. For 85.3{\%}, there was no change in use of a wheelchair. On a self-reported activity scale, 11.8{\%} improved, 8.8{\%} worsened and 79.4{\%} did not change. Work/school absenteeism averaged 2.7 (SD = 6.4) pre- and 1.5 (SD = 6.4, P = 0.26) days per year post-AA. While ankle ROM was significantly reduced post-AA, for most subjects, there was no change in use of AD/wheelchair for ambulation/mobility. Physical activity was maintained and work/school absenteeism remained stable.",
keywords = "ankle arthrodesis, ankle fusion, arthropathy, haemophilia, outcomes, range of motion",
author = "{Universal Data Collection Joint Outcome Working Group} and {Hemophilia Treatment Center Network Study Investigators} and H. Lane and Siddiqi, {A. E.A.} and Robina Ingram-Rich and P. Tobase and {Scott Ward}, R.",
year = "2014",
month = "9",
day = "1",
doi = "10.1111/hae.12398",
language = "English (US)",
volume = "20",
pages = "709--715",
journal = "Haemophilia",
issn = "1351-8216",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Functional outcomes following ankle arthrodesis in males with haemophilia

T2 - analyses using the CDC's Universal Data Collection surveillance project

AU - Universal Data Collection Joint Outcome Working Group

AU - Hemophilia Treatment Center Network Study Investigators

AU - Lane, H.

AU - Siddiqi, A. E.A.

AU - Ingram-Rich, Robina

AU - Tobase, P.

AU - Scott Ward, R.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - In persons with haemophilia (PWH), repeated ankle haemarthroses lead to pain, loss of joint range of motion (ROM), and limitations in activity and participation in society. PWH are offered ankle arthrodesis (AA) to eliminate pain. In our experience, PWH are hesitant to proceed to AA due to concerns regarding gait anomalies, functional decline and complete loss of ROM. The aim of this study was to report outcomes in ROM, assistive device (AD)/wheelchair use, activity scale and work/school absenteeism for participants in the CDC's Universal Data Collection surveillance project (UDC) pre- and post- AA. Males with haemophilia enrolled in the UDC with first report of AA (1998-2010) were selected. Descriptive statistics were calculated using data from the annual study visit pre-AA and the follow-up visit (~12-24 months) post-AA. The 68 subjects who fulfilled the criteria were: mean age 36.9 years (SD = 12.9); 85.3% white; 85.3% haemophilia A; 72% severe, 20.6% moderate; and 10.3% with inhibitor once during the study period. Mean loss in total arc of ankle motion was 17.02° (SD = 21.8, P ≤ 0.01) pre- compared to post-AA. For 61.8%, there was no change in use of AD for ambulation/mobility. For 85.3%, there was no change in use of a wheelchair. On a self-reported activity scale, 11.8% improved, 8.8% worsened and 79.4% did not change. Work/school absenteeism averaged 2.7 (SD = 6.4) pre- and 1.5 (SD = 6.4, P = 0.26) days per year post-AA. While ankle ROM was significantly reduced post-AA, for most subjects, there was no change in use of AD/wheelchair for ambulation/mobility. Physical activity was maintained and work/school absenteeism remained stable.

AB - In persons with haemophilia (PWH), repeated ankle haemarthroses lead to pain, loss of joint range of motion (ROM), and limitations in activity and participation in society. PWH are offered ankle arthrodesis (AA) to eliminate pain. In our experience, PWH are hesitant to proceed to AA due to concerns regarding gait anomalies, functional decline and complete loss of ROM. The aim of this study was to report outcomes in ROM, assistive device (AD)/wheelchair use, activity scale and work/school absenteeism for participants in the CDC's Universal Data Collection surveillance project (UDC) pre- and post- AA. Males with haemophilia enrolled in the UDC with first report of AA (1998-2010) were selected. Descriptive statistics were calculated using data from the annual study visit pre-AA and the follow-up visit (~12-24 months) post-AA. The 68 subjects who fulfilled the criteria were: mean age 36.9 years (SD = 12.9); 85.3% white; 85.3% haemophilia A; 72% severe, 20.6% moderate; and 10.3% with inhibitor once during the study period. Mean loss in total arc of ankle motion was 17.02° (SD = 21.8, P ≤ 0.01) pre- compared to post-AA. For 61.8%, there was no change in use of AD for ambulation/mobility. For 85.3%, there was no change in use of a wheelchair. On a self-reported activity scale, 11.8% improved, 8.8% worsened and 79.4% did not change. Work/school absenteeism averaged 2.7 (SD = 6.4) pre- and 1.5 (SD = 6.4, P = 0.26) days per year post-AA. While ankle ROM was significantly reduced post-AA, for most subjects, there was no change in use of AD/wheelchair for ambulation/mobility. Physical activity was maintained and work/school absenteeism remained stable.

KW - ankle arthrodesis

KW - ankle fusion

KW - arthropathy

KW - haemophilia

KW - outcomes

KW - range of motion

UR - http://www.scopus.com/inward/record.url?scp=85027951468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027951468&partnerID=8YFLogxK

U2 - 10.1111/hae.12398

DO - 10.1111/hae.12398

M3 - Article

C2 - 24629136

AN - SCOPUS:85027951468

VL - 20

SP - 709

EP - 715

JO - Haemophilia

JF - Haemophilia

SN - 1351-8216

IS - 5

ER -