Functional maturation of adult-generated granule cells

Linda S. Overstreet-Wadiche; Gary L. Westbrook

doi:10.1002/hipo.20152

Functional maturation of adult-generated granule cells

Linda S. Overstreet-Wadiche, Gary L. Westbrook

Vollum Institute

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

The excitability and connectivity of adult-generated granule cells dictate to what extent newborn neurons participate in the hippocampal network. These functional parameters evolve as newborn cells mature and interact with the existing circuit. The progression of granule cell maturation during neonatal development appears to be reiterated in the adult, but with some caveats. New approaches to identify and track newborn neurons are revealing the timing of this process, as well as its sensitivity to activity-dependent regulation.

Original language	English (US)
Pages (from-to)	208-215
Number of pages	8
Journal	Hippocampus
Volume	16
Issue number	3
DOIs	https://doi.org/10.1002/hipo.20152
State	Published - 2006

Keywords

Dentate gyrus
Hippocampus
Neurogenesis
Synaptic

ASJC Scopus subject areas

Cognitive Neuroscience

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10.1002/hipo.20152

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abstract = "The excitability and connectivity of adult-generated granule cells dictate to what extent newborn neurons participate in the hippocampal network. These functional parameters evolve as newborn cells mature and interact with the existing circuit. The progression of granule cell maturation during neonatal development appears to be reiterated in the adult, but with some caveats. New approaches to identify and track newborn neurons are revealing the timing of this process, as well as its sensitivity to activity-dependent regulation.",

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AB - The excitability and connectivity of adult-generated granule cells dictate to what extent newborn neurons participate in the hippocampal network. These functional parameters evolve as newborn cells mature and interact with the existing circuit. The progression of granule cell maturation during neonatal development appears to be reiterated in the adult, but with some caveats. New approaches to identify and track newborn neurons are revealing the timing of this process, as well as its sensitivity to activity-dependent regulation.

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KW - Neurogenesis

KW - Synaptic

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Functional maturation of adult-generated granule cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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