Functional magnetic resonance imaging of awake monkeys: Some approaches for improving imaging quality

Gang Chen, Feng Wang, Barbara C. Dillenburger, Robert M. Friedman, Li M. Chen, John C. Gore, Malcolm J. Avison, Anna Roe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Functional magnetic resonance imaging (fMRI) at high magnetic field strength can suffer from serious degradation of image quality because of motion and physiological noise, as well as spatial distortions and signal losses due to susceptibility effects. Overcoming such limitations is essential for sensitive detection and reliable interpretation of fMRI data. These issues are particularly problematic in studies of awake animals. As part of our initial efforts to study functional brain activations in awake, behaving monkeys using fMRI at 4.7 T, we have developed acquisition and analysis procedures to improve image quality with encouraging results. We evaluated the influence of two main variables on image quality. First, we show how important the level of behavioral training is for obtaining good data stability and high temporal signal-to-noise ratios. In initial sessions, our typical scan session lasted 1.5 h, partitioned into short (

Original languageEnglish (US)
Pages (from-to)36-47
Number of pages12
JournalMagnetic Resonance Imaging
Volume30
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Image quality
Haplorhini
Magnetic Resonance Imaging
Imaging techniques
Signal-To-Noise Ratio
Magnetic Fields
Noise
Brain
Signal to noise ratio
Animals
Chemical activation
Magnetic fields
Degradation

Keywords

  • Awake
  • Data stability
  • Functional MRI
  • Macaque monkey
  • Nonhuman primate
  • Visual cortex

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Functional magnetic resonance imaging of awake monkeys : Some approaches for improving imaging quality. / Chen, Gang; Wang, Feng; Dillenburger, Barbara C.; Friedman, Robert M.; Chen, Li M.; Gore, John C.; Avison, Malcolm J.; Roe, Anna.

In: Magnetic Resonance Imaging, Vol. 30, No. 1, 01.2012, p. 36-47.

Research output: Contribution to journalArticle

Chen, G, Wang, F, Dillenburger, BC, Friedman, RM, Chen, LM, Gore, JC, Avison, MJ & Roe, A 2012, 'Functional magnetic resonance imaging of awake monkeys: Some approaches for improving imaging quality', Magnetic Resonance Imaging, vol. 30, no. 1, pp. 36-47. https://doi.org/10.1016/j.mri.2011.09.010
Chen, Gang ; Wang, Feng ; Dillenburger, Barbara C. ; Friedman, Robert M. ; Chen, Li M. ; Gore, John C. ; Avison, Malcolm J. ; Roe, Anna. / Functional magnetic resonance imaging of awake monkeys : Some approaches for improving imaging quality. In: Magnetic Resonance Imaging. 2012 ; Vol. 30, No. 1. pp. 36-47.
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