Functional integration of acute myeloid leukemia into the vascular niche

C. R. Cogle, Devorah Goldman, G. J. Madlambayan, R. P. Leon, A. Al Masri, H. A. Clark, S. A. Asbaghi, Jeffrey Tyner, Jennifer Dunlap, Guang Fan, T. Kovacsovics, Q. Liu, A. Meacham, K. L. Hamlin, R. A. Hromas, E. W. Scott, William Fleming

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Vascular endothelial cells are a critical component of the hematopoietic microenvironment that regulates blood cell production. Recent studies suggest the existence of functional cross-talk between hematologic malignancies and vascular endothelium. Here we show that human acute myeloid leukemia (AML) localizes to the vasculature in both patients and in a xenograft model. A significant number of vascular tissue-associated AML cells (V-AML) integrate into vasculature in vivo and can fuse with endothelial cells. V-AML cells acquire several endothelial cell-like characteristics, including the upregulation of CD105, a receptor associated with activated endothelium. Remarkably, endothelial-integrated V-AML shows an almost fourfold reduction in proliferative activity compared with non-vascular-associated AML. Primary AML cells can be induced to downregulate the expression of their hematopoietic markers in vitro and differentiate into phenotypically and functionally defined endothelial-like cells. After transplantation, these leukemia-derived endothelial cells are capable of giving rise to AML. These novel functional interactions between AML cells and normal endothelium along with the reversible endothelial cell potential of AML suggest that vascular endothelium may serve as a previously unrecognized reservoir for AML.

Original languageEnglish (US)
Pages (from-to)1978-1987
Number of pages10
JournalLeukemia
Volume28
Issue number10
DOIs
StatePublished - Oct 1 2014

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Acute Myeloid Leukemia
Blood Vessels
Endothelial Cells
Myeloid Cells
Vascular Endothelium
Endothelium
Hematologic Neoplasms
Heterografts
Blood Cells
Leukemia
Up-Regulation
Down-Regulation
Transplantation

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine
  • Medicine(all)

Cite this

Cogle, C. R., Goldman, D., Madlambayan, G. J., Leon, R. P., Al Masri, A., Clark, H. A., ... Fleming, W. (2014). Functional integration of acute myeloid leukemia into the vascular niche. Leukemia, 28(10), 1978-1987. https://doi.org/10.1038/leu.2014.109

Functional integration of acute myeloid leukemia into the vascular niche. / Cogle, C. R.; Goldman, Devorah; Madlambayan, G. J.; Leon, R. P.; Al Masri, A.; Clark, H. A.; Asbaghi, S. A.; Tyner, Jeffrey; Dunlap, Jennifer; Fan, Guang; Kovacsovics, T.; Liu, Q.; Meacham, A.; Hamlin, K. L.; Hromas, R. A.; Scott, E. W.; Fleming, William.

In: Leukemia, Vol. 28, No. 10, 01.10.2014, p. 1978-1987.

Research output: Contribution to journalArticle

Cogle, CR, Goldman, D, Madlambayan, GJ, Leon, RP, Al Masri, A, Clark, HA, Asbaghi, SA, Tyner, J, Dunlap, J, Fan, G, Kovacsovics, T, Liu, Q, Meacham, A, Hamlin, KL, Hromas, RA, Scott, EW & Fleming, W 2014, 'Functional integration of acute myeloid leukemia into the vascular niche', Leukemia, vol. 28, no. 10, pp. 1978-1987. https://doi.org/10.1038/leu.2014.109
Cogle CR, Goldman D, Madlambayan GJ, Leon RP, Al Masri A, Clark HA et al. Functional integration of acute myeloid leukemia into the vascular niche. Leukemia. 2014 Oct 1;28(10):1978-1987. https://doi.org/10.1038/leu.2014.109
Cogle, C. R. ; Goldman, Devorah ; Madlambayan, G. J. ; Leon, R. P. ; Al Masri, A. ; Clark, H. A. ; Asbaghi, S. A. ; Tyner, Jeffrey ; Dunlap, Jennifer ; Fan, Guang ; Kovacsovics, T. ; Liu, Q. ; Meacham, A. ; Hamlin, K. L. ; Hromas, R. A. ; Scott, E. W. ; Fleming, William. / Functional integration of acute myeloid leukemia into the vascular niche. In: Leukemia. 2014 ; Vol. 28, No. 10. pp. 1978-1987.
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