Functional genomics in virology and antiviral drug discovery

Victor DeFilippis, Camilo Raggo, Ashlee Moses, Klaus Früh

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Virology research and antiviral drug discovery are poised to benefit from the post-genomic revolution for three main reasons. First, viruses need the host to replicate and are therefore vulnerable to inhibition of cellular pathways. Knowledge of complete genomic sequences of both virus and host now permits the study of this interplay on a global scale. Combining transcriptomics and proteomics with large-scale gene knockdown experiments will enable the identification of novel antiviral targets. Second, massive parallel assay systems, such as DNA microarrays, which define the post-genomic era, will facilitate viral diagnostics. Third, the combination of genetics with genomics will enable the analysis of viral mutants and strains on an unprecedented scale. The dramatic effects of viral infection on host cell transcriptional patterns have been well-documented and will be briefly highlighted. In addition, we discuss recent trends that apply functional genomics methods to the discovery of new targets and therapies for viral disease.

Original languageEnglish (US)
Pages (from-to)452-457
Number of pages6
JournalTrends in biotechnology
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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