Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation

Bertrand P. Tseng, Erich Giedzinski, Atefeh Izadi, Tatiana Suarez, Mary L. Lan, Katherine K. Tran, Munjal M. Acharya, Gregory A. Nelson, Jacob Raber, Vipan K. Parihar, Charles L. Limoli

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Aims: Redox homeostasis is critical in regulating the fate and function of multipotent cells in the central nervous system (CNS). Here, we investigated whether low dose charged particle irradiation could elicit oxidative stress in neural stem and precursor cells and whether radiation-induced changes in redox metabolism would coincide with cognitive impairment. Results: Low doses (

Original languageEnglish (US)
Pages (from-to)1410-1422
Number of pages13
JournalAntioxidants and Redox Signaling
Volume20
Issue number9
DOIs
StatePublished - Mar 20 2014

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Oxidative stress
Neural Stem Cells
Charged particles
Stem cells
Oxidation-Reduction
Brain
Oxidative Stress
Irradiation
Radiation
Neurology
Metabolism
Dosimetry
Homeostasis
Central Nervous System
Cognitive Dysfunction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation. / Tseng, Bertrand P.; Giedzinski, Erich; Izadi, Atefeh; Suarez, Tatiana; Lan, Mary L.; Tran, Katherine K.; Acharya, Munjal M.; Nelson, Gregory A.; Raber, Jacob; Parihar, Vipan K.; Limoli, Charles L.

In: Antioxidants and Redox Signaling, Vol. 20, No. 9, 20.03.2014, p. 1410-1422.

Research output: Contribution to journalArticle

Tseng, BP, Giedzinski, E, Izadi, A, Suarez, T, Lan, ML, Tran, KK, Acharya, MM, Nelson, GA, Raber, J, Parihar, VK & Limoli, CL 2014, 'Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation', Antioxidants and Redox Signaling, vol. 20, no. 9, pp. 1410-1422. https://doi.org/10.1089/ars.2012.5134
Tseng, Bertrand P. ; Giedzinski, Erich ; Izadi, Atefeh ; Suarez, Tatiana ; Lan, Mary L. ; Tran, Katherine K. ; Acharya, Munjal M. ; Nelson, Gregory A. ; Raber, Jacob ; Parihar, Vipan K. ; Limoli, Charles L. / Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation. In: Antioxidants and Redox Signaling. 2014 ; Vol. 20, No. 9. pp. 1410-1422.
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