Functional consequence of the MET-T1010I polymorphism in breast cancer

Shuying Liu, Funda Meric-Bernstam, Napa Parinyanitikul, Bailiang Wang, Agda K. Eterovic, Xiaofeng Zheng, Mihai Gagea, Mariana Chavez-MacGregor, Naoto T. Ueno, Xiudong Lei, Wanding Zhou, Lakshmy Nair, Debu Tripathy, Powel H. Brown, Gabriel N. Hortobagyi, Ken Chen, John Mendelsohn, Gordon Mills, Ana M. Gonzalez-Angulo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an uncommon germline single nucleotide polymorphism (SNP), MET-T1010I, in many cancer lineages including breast cancer where the MET-T1010I SNP is present in 2% of patients with metastatic breast cancer. Expression of MET-T1010I in the context of mammary epithelium increases colony formation, cell migration and invasion invitro and tumor growth and invasion in-vivo. A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials.

Original languageEnglish (US)
Pages (from-to)2604-2614
Number of pages11
JournalOncotarget
Volume6
Issue number5
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Breast Neoplasms
Single Nucleotide Polymorphism
Neoplasms
Growth Factor Receptors
Neoplasm Genes
Cell Movement
Breast
Epithelium
Biomarkers
Clinical Trials
Growth
Familial Breast Cancer
In Vitro Techniques

Keywords

  • Breast cancer
  • Malignant transformation
  • MET mutations

ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

Cite this

Liu, S., Meric-Bernstam, F., Parinyanitikul, N., Wang, B., Eterovic, A. K., Zheng, X., ... Gonzalez-Angulo, A. M. (2015). Functional consequence of the MET-T1010I polymorphism in breast cancer. Oncotarget, 6(5), 2604-2614.

Functional consequence of the MET-T1010I polymorphism in breast cancer. / Liu, Shuying; Meric-Bernstam, Funda; Parinyanitikul, Napa; Wang, Bailiang; Eterovic, Agda K.; Zheng, Xiaofeng; Gagea, Mihai; Chavez-MacGregor, Mariana; Ueno, Naoto T.; Lei, Xiudong; Zhou, Wanding; Nair, Lakshmy; Tripathy, Debu; Brown, Powel H.; Hortobagyi, Gabriel N.; Chen, Ken; Mendelsohn, John; Mills, Gordon; Gonzalez-Angulo, Ana M.

In: Oncotarget, Vol. 6, No. 5, 01.01.2015, p. 2604-2614.

Research output: Contribution to journalArticle

Liu, S, Meric-Bernstam, F, Parinyanitikul, N, Wang, B, Eterovic, AK, Zheng, X, Gagea, M, Chavez-MacGregor, M, Ueno, NT, Lei, X, Zhou, W, Nair, L, Tripathy, D, Brown, PH, Hortobagyi, GN, Chen, K, Mendelsohn, J, Mills, G & Gonzalez-Angulo, AM 2015, 'Functional consequence of the MET-T1010I polymorphism in breast cancer', Oncotarget, vol. 6, no. 5, pp. 2604-2614.
Liu S, Meric-Bernstam F, Parinyanitikul N, Wang B, Eterovic AK, Zheng X et al. Functional consequence of the MET-T1010I polymorphism in breast cancer. Oncotarget. 2015 Jan 1;6(5):2604-2614.
Liu, Shuying ; Meric-Bernstam, Funda ; Parinyanitikul, Napa ; Wang, Bailiang ; Eterovic, Agda K. ; Zheng, Xiaofeng ; Gagea, Mihai ; Chavez-MacGregor, Mariana ; Ueno, Naoto T. ; Lei, Xiudong ; Zhou, Wanding ; Nair, Lakshmy ; Tripathy, Debu ; Brown, Powel H. ; Hortobagyi, Gabriel N. ; Chen, Ken ; Mendelsohn, John ; Mills, Gordon ; Gonzalez-Angulo, Ana M. / Functional consequence of the MET-T1010I polymorphism in breast cancer. In: Oncotarget. 2015 ; Vol. 6, No. 5. pp. 2604-2614.
@article{135c0ed62bbf47c9bc007fb2c5df78c4,
title = "Functional consequence of the MET-T1010I polymorphism in breast cancer",
abstract = "Major breast cancer predisposition genes, only account for approximately 30{\%} of high-risk breast cancer families and only explain 15{\%} of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an uncommon germline single nucleotide polymorphism (SNP), MET-T1010I, in many cancer lineages including breast cancer where the MET-T1010I SNP is present in 2{\%} of patients with metastatic breast cancer. Expression of MET-T1010I in the context of mammary epithelium increases colony formation, cell migration and invasion invitro and tumor growth and invasion in-vivo. A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials.",
keywords = "Breast cancer, Malignant transformation, MET mutations",
author = "Shuying Liu and Funda Meric-Bernstam and Napa Parinyanitikul and Bailiang Wang and Eterovic, {Agda K.} and Xiaofeng Zheng and Mihai Gagea and Mariana Chavez-MacGregor and Ueno, {Naoto T.} and Xiudong Lei and Wanding Zhou and Lakshmy Nair and Debu Tripathy and Brown, {Powel H.} and Hortobagyi, {Gabriel N.} and Ken Chen and John Mendelsohn and Gordon Mills and Gonzalez-Angulo, {Ana M.}",
year = "2015",
month = "1",
day = "1",
language = "English (US)",
volume = "6",
pages = "2604--2614",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "5",

}

TY - JOUR

T1 - Functional consequence of the MET-T1010I polymorphism in breast cancer

AU - Liu, Shuying

AU - Meric-Bernstam, Funda

AU - Parinyanitikul, Napa

AU - Wang, Bailiang

AU - Eterovic, Agda K.

AU - Zheng, Xiaofeng

AU - Gagea, Mihai

AU - Chavez-MacGregor, Mariana

AU - Ueno, Naoto T.

AU - Lei, Xiudong

AU - Zhou, Wanding

AU - Nair, Lakshmy

AU - Tripathy, Debu

AU - Brown, Powel H.

AU - Hortobagyi, Gabriel N.

AU - Chen, Ken

AU - Mendelsohn, John

AU - Mills, Gordon

AU - Gonzalez-Angulo, Ana M.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an uncommon germline single nucleotide polymorphism (SNP), MET-T1010I, in many cancer lineages including breast cancer where the MET-T1010I SNP is present in 2% of patients with metastatic breast cancer. Expression of MET-T1010I in the context of mammary epithelium increases colony formation, cell migration and invasion invitro and tumor growth and invasion in-vivo. A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials.

AB - Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an uncommon germline single nucleotide polymorphism (SNP), MET-T1010I, in many cancer lineages including breast cancer where the MET-T1010I SNP is present in 2% of patients with metastatic breast cancer. Expression of MET-T1010I in the context of mammary epithelium increases colony formation, cell migration and invasion invitro and tumor growth and invasion in-vivo. A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials.

KW - Breast cancer

KW - Malignant transformation

KW - MET mutations

UR - http://www.scopus.com/inward/record.url?scp=84923279397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923279397&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 2604

EP - 2614

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 5

ER -