@article{26030c7bbe654481ac45358a98aa5f4b,
title = "Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder",
abstract = "Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.",
keywords = "Amygdala, Bipolar disorder, FMRI, Prefrontal cortex",
author = "Chepenik, {Lara G.} and Mariella Raffo and Michelle Hampson and Cheryl Lacadie and Fei Wang and Jones, {Monique M.} and Brian Pittman and Pawel Skudlarski and Blumberg, {Hilary P.}",
note = "Funding Information: This article is dedicated to Ms. Kathleen Colonese who was devoted to helping those suffering from psychiatric illnesses and whose kindness to colleagues and participants alike touched us all. We give thanks to all of the participants in this study, and hope that this work may one day contribute to helping those living with bipolar disorder. We would also like to thank Terry Hickey, R.T.R.M.R. and Hedy Sarofin, R.T.R.M.R. for their technical expertise, and acknowledge the help and support of all members of the Mood Disorders Laboratory at Yale. The authors were supported by research grants from the Department of Veterans Affairs Research Career Development (HPB), Merit Review (HPB) and Research Enhancement Award Program (REAP) Awards (LGC, HPB); the National Institute of Mental Health R01MH070902 (HPB), T32MH14276 (LGC); the National Alliance for Research on Schizophrenia and Depression (Great Neck, NY) (HPB); the Attias Family Foundation (HPB); and the Ethel F. Donaghue Women's Investigator Program at Yale (New Haven, CT) (HPB).",
year = "2010",
month = jun,
day = "30",
doi = "10.1016/j.pscychresns.2010.04.002",
language = "English (US)",
volume = "182",
pages = "207--210",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "3",
}