Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder

Lara G. Chepenik, Mariella Raffo, Michelle Hampson, Cheryl Lacadie, Fei Wang, Monique M. Jones, Brian Pittman, Pawel Skudlarski, Hilary P. Blumberg

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.

Original languageEnglish (US)
Pages (from-to)207-210
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume182
Issue number3
DOIs
StatePublished - Jun 30 2010
Externally publishedYes

Keywords

  • Amygdala
  • Bipolar disorder
  • FMRI
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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