Functional Connectivity and Tuning Curves in Populations of Simultaneously Recorded Neurons

Ian H. Stevenson, Brian M. London, Emily R. Oby, Nicholas A. Sachs, Jacob Reimer, Bernhard Englitz, Stephen V. David, Shihab A. Shamma, Timothy J. Blanche, Kenji Mizuseki, Amin Zandvakili, Nicholas G. Hatsopoulos, Lee E. Miller, Konrad P. Kording

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

How interactions between neurons relate to tuned neural responses is a longstanding question in systems neuroscience. Here we use statistical modeling and simultaneous multi-electrode recordings to explore the relationship between these interactions and tuning curves in six different brain areas. We find that, in most cases, functional interactions between neurons provide an explanation of spiking that complements and, in some cases, surpasses the influence of canonical tuning curves. Modeling functional interactions improves both encoding and decoding accuracy by accounting for noise correlations and features of the external world that tuning curves fail to capture. In cortex, modeling coupling alone allows spikes to be predicted more accurately than tuning curve models based on external variables. These results suggest that statistical models of functional interactions between even relatively small numbers of neurons may provide a useful framework for examining neural coding.

Original languageEnglish (US)
Article numbere1002775
JournalPLoS computational biology
Volume8
Issue number11
DOIs
StatePublished - Nov 2012

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

Fingerprint Dive into the research topics of 'Functional Connectivity and Tuning Curves in Populations of Simultaneously Recorded Neurons'. Together they form a unique fingerprint.

  • Cite this

    Stevenson, I. H., London, B. M., Oby, E. R., Sachs, N. A., Reimer, J., Englitz, B., David, S. V., Shamma, S. A., Blanche, T. J., Mizuseki, K., Zandvakili, A., Hatsopoulos, N. G., Miller, L. E., & Kording, K. P. (2012). Functional Connectivity and Tuning Curves in Populations of Simultaneously Recorded Neurons. PLoS computational biology, 8(11), [e1002775]. https://doi.org/10.1371/journal.pcbi.1002775