Functional changes in inner retinal neurons in animal models of photoreceptor degeneration

Teresa Puthussery, William Taylor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Citations (Scopus)

Abstract

Retinitis Pigmentosa (RP) refers to a heterogeneous group of inherited disorders that result in the death of rod and cone photoreceptors. There is now abundant evidence to suggest that inner retinal neurons, particularly the bipolar and horizontal cells, undergo significant morphological changes and changes in neurotransmitter receptor expression in response to photoreceptor degeneration. Some of these alterations could impact the choice and success of intervention strategies for these conditions, and it is therefore necessary to understand the timing and nature of any functional deficits resulting from degenerative changes. This paper will review the evidence for functional alterations in the inner retina in animal models of (RP), with particular emphasis on the bipolar and ganglion cells.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages525-532
Number of pages8
Volume664
DOIs
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume664
ISSN (Print)00652598

Fingerprint

Retinal Neurons
Neurotransmitter Receptor
Retinitis Pigmentosa
Neurons
Cones
Animals
Animal Models
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
Ganglia
Retina

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Puthussery, T., & Taylor, W. (2010). Functional changes in inner retinal neurons in animal models of photoreceptor degeneration. In Advances in Experimental Medicine and Biology (Vol. 664, pp. 525-532). (Advances in Experimental Medicine and Biology; Vol. 664). https://doi.org/10.1007/978-1-4419-1399-9_60

Functional changes in inner retinal neurons in animal models of photoreceptor degeneration. / Puthussery, Teresa; Taylor, William.

Advances in Experimental Medicine and Biology. Vol. 664 2010. p. 525-532 (Advances in Experimental Medicine and Biology; Vol. 664).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Puthussery, T & Taylor, W 2010, Functional changes in inner retinal neurons in animal models of photoreceptor degeneration. in Advances in Experimental Medicine and Biology. vol. 664, Advances in Experimental Medicine and Biology, vol. 664, pp. 525-532. https://doi.org/10.1007/978-1-4419-1399-9_60
Puthussery T, Taylor W. Functional changes in inner retinal neurons in animal models of photoreceptor degeneration. In Advances in Experimental Medicine and Biology. Vol. 664. 2010. p. 525-532. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-1399-9_60
Puthussery, Teresa ; Taylor, William. / Functional changes in inner retinal neurons in animal models of photoreceptor degeneration. Advances in Experimental Medicine and Biology. Vol. 664 2010. pp. 525-532 (Advances in Experimental Medicine and Biology).
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