Abstract
Retinitis Pigmentosa (RP) refers to a heterogeneous group of inherited disorders that result in the death of rod and cone photoreceptors. There is now abundant evidence to suggest that inner retinal neurons, particularly the bipolar and horizontal cells, undergo significant morphological changes and changes in neurotransmitter receptor expression in response to photoreceptor degeneration. Some of these alterations could impact the choice and success of intervention strategies for these conditions, and it is therefore necessary to understand the timing and nature of any functional deficits resulting from degenerative changes. This paper will review the evidence for functional alterations in the inner retina in animal models of (RP), with particular emphasis on the bipolar and ganglion cells.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Pages | 525-532 |
| Number of pages | 8 |
| Volume | 664 |
| DOIs | |
| State | Published - 2010 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 664 |
| ISSN (Print) | 00652598 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Functional changes in inner retinal neurons in animal models of photoreceptor degeneration. / Puthussery, Teresa; Taylor, William.
Advances in Experimental Medicine and Biology. Vol. 664 2010. p. 525-532 (Advances in Experimental Medicine and Biology; Vol. 664).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Functional changes in inner retinal neurons in animal models of photoreceptor degeneration
AU - Puthussery, Teresa
AU - Taylor, William
PY - 2010
Y1 - 2010
N2 - Retinitis Pigmentosa (RP) refers to a heterogeneous group of inherited disorders that result in the death of rod and cone photoreceptors. There is now abundant evidence to suggest that inner retinal neurons, particularly the bipolar and horizontal cells, undergo significant morphological changes and changes in neurotransmitter receptor expression in response to photoreceptor degeneration. Some of these alterations could impact the choice and success of intervention strategies for these conditions, and it is therefore necessary to understand the timing and nature of any functional deficits resulting from degenerative changes. This paper will review the evidence for functional alterations in the inner retina in animal models of (RP), with particular emphasis on the bipolar and ganglion cells.
AB - Retinitis Pigmentosa (RP) refers to a heterogeneous group of inherited disorders that result in the death of rod and cone photoreceptors. There is now abundant evidence to suggest that inner retinal neurons, particularly the bipolar and horizontal cells, undergo significant morphological changes and changes in neurotransmitter receptor expression in response to photoreceptor degeneration. Some of these alterations could impact the choice and success of intervention strategies for these conditions, and it is therefore necessary to understand the timing and nature of any functional deficits resulting from degenerative changes. This paper will review the evidence for functional alterations in the inner retina in animal models of (RP), with particular emphasis on the bipolar and ganglion cells.
UR - http://www.scopus.com/inward/record.url?scp=79551639479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551639479&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-1399-9_60
DO - 10.1007/978-1-4419-1399-9_60
M3 - Conference contribution
C2 - 20238055
AN - SCOPUS:79551639479
SN - 9781441913982
VL - 664
T3 - Advances in Experimental Medicine and Biology
SP - 525
EP - 532
BT - Advances in Experimental Medicine and Biology
ER -