Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR

Mark Slifka, J. Lindsay Whitton

    Research output: Contribution to journalArticle

    291 Citations (Scopus)

    Abstract

    Unlike B cells, T cells lack the capacity to improve the affinity of their antigen receptors by somatic mutation. It is, therefore, believed that optimization of cellular immunity is mediated almost exclusively through selective expansion of T cells bearing receptors with the highest affinity for antigen. We show here that T cell responsiveness to peptide (termed "functional avidity") increased>50-fold during the early stages of viral infection. This indicated that T cells, like B cells, undergo extensive functional maturation in vivo. However, in contrast to B cells, maturation of the T cell response can occur without any appreciable change in T cell receptor affinity.

    Original languageEnglish (US)
    Pages (from-to)711-717
    Number of pages7
    JournalNature Immunology
    Volume2
    Issue number8
    DOIs
    StatePublished - 2001

    Fingerprint

    T-Lymphocytes
    B-Lymphocytes
    T-Cell Antigen Receptor
    Antigen Receptors
    Virus Diseases
    Cellular Immunity
    Antigens
    Peptides
    Mutation

    ASJC Scopus subject areas

    • Immunology

    Cite this

    Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR. / Slifka, Mark; Whitton, J. Lindsay.

    In: Nature Immunology, Vol. 2, No. 8, 2001, p. 711-717.

    Research output: Contribution to journalArticle

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