Functional analysis of Leishmania membrane (Non-ABC) transporters involved in drug resistance

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Leishmania parasites rely heavily upon membrane transport proteins to deliver essential nutrients from their hosts to the interior of the parasite. Some of these transporters also serve as routes for uptake of drugs used for treatment of leishmaniasis or experimental drugs with potential for development of novel anti-leishmanial therapies. Hence, mutations within the coding regions of such permeases or alterations in the expression of the carrier proteins can confer drug resistance upon the parasites. This chapter reviews the current level of knowledge regarding several classes of membrane transporters known to play roles in uptake or sensitivity to drugs. The increasing knowledge of the "permeome," provided by complete genome sequences of several Leishmania species, has advanced considerably our knowledge of how nutrients and drugs or other cytotoxic compounds enter these pathogenic protozoa. Recent genome-wide approaches to functional analysis promise to further our understanding of transporters as determinants of drug sensitivity and resistance.

Original languageEnglish (US)
Title of host publicationDrug Resistance in Leishmania Parasites
Subtitle of host publicationConsequences, Molecular Mechanisms and Possible Treatments
PublisherSpringer International Publishing
Pages273-294
Number of pages22
ISBN (Electronic)9783319741864
ISBN (Print)9783319741857
DOIs
Publication statusPublished - Aug 23 2018

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ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Immunology and Microbiology(all)

Cite this

Landfear, S. (2018). Functional analysis of Leishmania membrane (Non-ABC) transporters involved in drug resistance. In Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments (pp. 273-294). Springer International Publishing. https://doi.org/10.1007/978-3-319-74186-4_12