Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Leishmania parasites rely heavily upon membrane transport proteins to deliver essential nutrients from their hosts to the interior of the parasite. Some of these transporters also serve as routes for uptake of drugs used for treatment of leishmaniasis or experimental drugs with potentialfor development of novel anti-leishmanial therapies. Hence, mutations within the coding regions of such permeases or alterations in the expression of the carrier proteins can confer drug resistance upon the parasites. This chapter reviews the current level of knowledge regarding several classes of membrane transporters known to play roles in uptake or sensitivity to drugs. The increasing knowledge of the ’permeome,– provided by complete genome sequences of several Leishmania species, has advanced considerably our knowledge of how nutrients and drugs or other cytotoxic compounds enterthese pathogenic protozoa.

Original languageEnglish (US)
Title of host publicationDrug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments
PublisherSpringer-Verlag Wien
Pages259-284
Number of pages26
ISBN (Print)9783709111253, 9783709102381
DOIs
StatePublished - Jan 1 2013

Fingerprint

Leishmania
Drug Resistance
Membrane Transport Proteins
Parasites
Membranes
Pharmaceutical Preparations
Food
Leishmaniasis
Carrier Proteins
Genome
Mutation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Landfear, S. (2013). Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance. In Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments (pp. 259-284). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-1125-3_13

Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance. / Landfear, Scott.

Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments. Springer-Verlag Wien, 2013. p. 259-284.

Research output: Chapter in Book/Report/Conference proceedingChapter

Landfear, S 2013, Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance. in Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments. Springer-Verlag Wien, pp. 259-284. https://doi.org/10.1007/978-3-7091-1125-3_13
Landfear S. Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance. In Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments. Springer-Verlag Wien. 2013. p. 259-284 https://doi.org/10.1007/978-3-7091-1125-3_13
Landfear, Scott. / Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance. Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments. Springer-Verlag Wien, 2013. pp. 259-284
@inbook{bcbd31f159374041bc6a3efd031b7448,
title = "Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance",
abstract = "Leishmania parasites rely heavily upon membrane transport proteins to deliver essential nutrients from their hosts to the interior of the parasite. Some of these transporters also serve as routes for uptake of drugs used for treatment of leishmaniasis or experimental drugs with potentialfor development of novel anti-leishmanial therapies. Hence, mutations within the coding regions of such permeases or alterations in the expression of the carrier proteins can confer drug resistance upon the parasites. This chapter reviews the current level of knowledge regarding several classes of membrane transporters known to play roles in uptake or sensitivity to drugs. The increasing knowledge of the ’permeome,– provided by complete genome sequences of several Leishmania species, has advanced considerably our knowledge of how nutrients and drugs or other cytotoxic compounds enterthese pathogenic protozoa.",
author = "Scott Landfear",
year = "2013",
month = "1",
day = "1",
doi = "10.1007/978-3-7091-1125-3_13",
language = "English (US)",
isbn = "9783709111253",
pages = "259--284",
booktitle = "Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments",
publisher = "Springer-Verlag Wien",

}

TY - CHAP

T1 - Functional analysis of leishmania membrane (Non-ABC) transporters involved in drug resistance

AU - Landfear, Scott

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Leishmania parasites rely heavily upon membrane transport proteins to deliver essential nutrients from their hosts to the interior of the parasite. Some of these transporters also serve as routes for uptake of drugs used for treatment of leishmaniasis or experimental drugs with potentialfor development of novel anti-leishmanial therapies. Hence, mutations within the coding regions of such permeases or alterations in the expression of the carrier proteins can confer drug resistance upon the parasites. This chapter reviews the current level of knowledge regarding several classes of membrane transporters known to play roles in uptake or sensitivity to drugs. The increasing knowledge of the ’permeome,– provided by complete genome sequences of several Leishmania species, has advanced considerably our knowledge of how nutrients and drugs or other cytotoxic compounds enterthese pathogenic protozoa.

AB - Leishmania parasites rely heavily upon membrane transport proteins to deliver essential nutrients from their hosts to the interior of the parasite. Some of these transporters also serve as routes for uptake of drugs used for treatment of leishmaniasis or experimental drugs with potentialfor development of novel anti-leishmanial therapies. Hence, mutations within the coding regions of such permeases or alterations in the expression of the carrier proteins can confer drug resistance upon the parasites. This chapter reviews the current level of knowledge regarding several classes of membrane transporters known to play roles in uptake or sensitivity to drugs. The increasing knowledge of the ’permeome,– provided by complete genome sequences of several Leishmania species, has advanced considerably our knowledge of how nutrients and drugs or other cytotoxic compounds enterthese pathogenic protozoa.

UR - http://www.scopus.com/inward/record.url?scp=84957011287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957011287&partnerID=8YFLogxK

U2 - 10.1007/978-3-7091-1125-3_13

DO - 10.1007/978-3-7091-1125-3_13

M3 - Chapter

SN - 9783709111253

SN - 9783709102381

SP - 259

EP - 284

BT - Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments

PB - Springer-Verlag Wien

ER -