Function of the her‐1 gene is required for maintenance of male differentiation in adult tissues of C. elegans

Pepper Schedin, Petra Jonas, William B. Wood

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Function of the sex‐determining gene her‐1 is required in XO embryos cf C. elegans to specify male development. Using a temperature‐sensitive mutant of her‐1, we show that when XO males reared at a permissive temperature are shifted as adults to a nonpermissive temperature, they initiate vitellogenin synthesis in the intestine and oocyte production in the germline. A similar shift has no effect on her‐1(+) males. We conclude that sexual differentiation of the intestine and germline is plastic, requiring her‐1 expression throughout adulthood for maintenance of the male state. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalDevelopmental Genetics
Volume15
Issue number3
DOIs
StatePublished - 1994

Keywords

  • Commitment
  • differentiation
  • sex determination

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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