Full-Thickness Lamellar Keratoplasty: A Histologic Study in Human Eyes

John C. Morrison, Kenneth C. Swan

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Four human eyes, obtained 38 days to 5 years after fullthickness lamellar keratoplasty, were studied by light microscopy for evidence of fibroblast proliferation and collagen formation between the donor Descemet's membrane and the recipient stromal bed. There was delayed healing in the membrane to stroma interface, but at the graft margins a relatively normal stroma-to-stroma healing response was evident. Even in the five-year specimen, bridging of recipient collagen to donor Descemet's membrane was noted only where it was associated with subgraft vascularization. All donor endothelium had disappeared. These studies indicate that in human eyes, retention of Descemet's membrane results in a weaker total graft-host bond than provided by conventional lamellar keratoplasty. In addition, this altered healing may predispose to pseudoanterior chambers that may decrease visual acuity and diminish the theoretical optical advantages of a smooth Descemet's membrane in the graft host interface.

Original languageEnglish (US)
Pages (from-to)715-719
Number of pages5
Issue number6
StatePublished - 1982


  • Descemet's membrane
  • full-thickness corneal grafts
  • lamellar keratoplasty
  • pseudoanterior chamber
  • wound healing

ASJC Scopus subject areas

  • Ophthalmology


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