Full-thickness lamellar keratoplasty. A histologic study in human eyes

John Morrison, K. C. Swan

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Four human eyes, obtained 38 days to 5 years after full-thickness lamellar keratoplasty, were studied by light microscopy for evidence of fibroblast proliferation and collagen formation between the donor Descemet's membrane and the recipient stromal bed. There was delayed healing in the membrane to stroma interface, but at the graft margins a relatively normal stroma-to-stroma healing response was evident. Even in the five-year specimen, bridging of recipient collagen to donor Descemet's membrane was noted only where it was associated with subgraft vascularization. All donor endothelium had disappeared. These studies indicate that in human eyes, retention of Descemet's membrane results in a weaker total graft-host bond than provided by conventional lamellar keratoplasty. In addition, this altered healing may predispose to pseudoanterior chambers that may decrease visual acuity and diminish the theoretical optical advantages of a smooth Descemet's membrane in the graft host interface.

Original languageEnglish (US)
Pages (from-to)715-719
Number of pages5
JournalOphthalmology
Volume89
Issue number6
StatePublished - 1982

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Descemet Membrane
Corneal Transplantation
Transplants
Collagen
Visual Acuity
Endothelium
Microscopy
Fibroblasts
Light
Membranes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Full-thickness lamellar keratoplasty. A histologic study in human eyes. / Morrison, John; Swan, K. C.

In: Ophthalmology, Vol. 89, No. 6, 1982, p. 715-719.

Research output: Contribution to journalArticle

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