Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species

Daniel Malouli, Grant L. Howell, Alfred W. Legasse, Christoph Kahl, Michael Axthelm, Scott Hansen, Klaus Frueh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Multiple novel simian adenoviruses have been isolated over the past years and their potential to cross the species barrier and infect the human population is an ever present threat. Here we describe the isolation and full genome sequencing of a novel simian adenovirus (SAdV) isolated from the urine of two independent, never co-housed, late stage simian immunodeficiency virus (SIV)-infected rhesus macaques. The viral genome sequences revealed a novel type with a unique genome length, GC content, E3 region and DNA polymerase amino acid sequence that is sufficiently distinct from all currently known human- or simian adenovirus species to warrant classifying these isolates as a novel species of simian adenovirus. This new species, termed Simian mastadenovirus D (SAdV-D), displays the standard genome organization for the genus Mastadenovirus containing only one copy of the fiber gene which sets it apart from the old world monkey adenovirus species HAdV-G, SAdV-B and SAdV-C.

Original languageEnglish (US)
Pages (from-to)18-29
Number of pages12
JournalVirology Reports
Volume3
DOIs
StatePublished - Sep 1 2014

Fingerprint

Simian Adenoviruses
Macaca mulatta
Adenoviridae
Sequence Analysis
Genes
Genome
Mastadenovirus
Cercopithecidae
Human Adenoviruses
DNA-Directed DNA Polymerase
Simian Immunodeficiency Virus
Viruses
Viral Genome
Base Composition
Amino Acid Sequence
Amino Acids
Urine
Fibers

Keywords

  • Adenovirus
  • Adenovirus species
  • Non-human primate
  • Rhesus macaque
  • Simian adenovirus
  • Virus genome analysis
  • Virus phylogenomics

ASJC Scopus subject areas

  • Virology
  • Biochemistry

Cite this

Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species. / Malouli, Daniel; Howell, Grant L.; Legasse, Alfred W.; Kahl, Christoph; Axthelm, Michael; Hansen, Scott; Frueh, Klaus.

In: Virology Reports, Vol. 3, 01.09.2014, p. 18-29.

Research output: Contribution to journalArticle

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