Full diffusion characterization implicates regionally disparate neuropathology in Mild Cognitive Impairment

Erin Boespflug, Judd Storrs, Sara Sadat-Hossieny, James Eliassen, Marcelle Shidler, Matthew Norris, Robert Krikorian

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diffusion tensor imaging (DTI) is used to detect tissue pathology. In Alzheimer's disease (AD) research, DTI has been used to elucidate differences in disease stages and to track progression over time and clinical severity. Many of these studies have identified the fornix as particularly vulnerable in the early stages of pathology associated with memory decline in prodromal AD. Emerging research suggests principal tensor components, axial (DA) and radial (DR) diffusivity, are more sensitive to underlying tissue pathology than are mean diffusivity (MD) and fractional anisotropy (FA). Given the established regionally specific tissue decline in MCI, we examined components of the full diffusion tensor (MD, FA, DR, and DA) for sensitivity to regional pathology associated with specific memory deficits in 18 individuals with MCI. We investigated multiple regions of interest, including fornix, temporal stem, and control regions for association with severity of impairment on multiple memory measures, including a type of neuropsychological task shown to be particularly sensitive to early memory decline in MCI. Better paired associate learning was selectively associated with lower DA (β = -0.663, p = 0.003), but not with DR, MD, or FA of the temporal stems. Conversely, better paired associate learning was associated with lower DR (β = -0.523, p = 0.026), higher FA (β = 0.498, p = 0.036), and lower MD (β = -0.513, p = 0.030), but not DA in the fornix. No association was found for control regions, or for control cognitive measures. These findings suggest disparate pathology of temporal stems and fornix white matter in association with early memory impairment in MCI. Further, they highlight the methodological importance of evaluating the full tensor, rather than only summative metrics in research using DTI.

Original languageEnglish (US)
Pages (from-to)367-379
Number of pages13
JournalBrain Structure and Function
Volume219
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Anisotropy
Diffusion Tensor Imaging
Pathology
Paired-Associate Learning
Alzheimer Disease
Research
Memory Disorders
Cognitive Dysfunction
Neuropathology

Keywords

  • Alzheimer's disease
  • Associative learning
  • Diffusion tensor imaging
  • Fornix
  • Mild Cognitive Impairment
  • Radial diffusivity

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology

Cite this

Full diffusion characterization implicates regionally disparate neuropathology in Mild Cognitive Impairment. / Boespflug, Erin; Storrs, Judd; Sadat-Hossieny, Sara; Eliassen, James; Shidler, Marcelle; Norris, Matthew; Krikorian, Robert.

In: Brain Structure and Function, Vol. 219, No. 1, 01.01.2014, p. 367-379.

Research output: Contribution to journalArticle

Boespflug, Erin ; Storrs, Judd ; Sadat-Hossieny, Sara ; Eliassen, James ; Shidler, Marcelle ; Norris, Matthew ; Krikorian, Robert. / Full diffusion characterization implicates regionally disparate neuropathology in Mild Cognitive Impairment. In: Brain Structure and Function. 2014 ; Vol. 219, No. 1. pp. 367-379.
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