Plasma and urinary follicle stimuulating hormone, plasma estradiol, and plasma testosterone were measured prior to and after a 4-day hCG provocative test (4000 IU/day) in 6 normal men and in 5 patients with deficient gonadal steroidogenesis ("agonadal"). Plasma and urinary FSH decreased significantly (p < .01) after hCG treatment in the normal men but did not change in the "agonadal" subjects. Mean plasma estradiol rose from 33.4 pg/ml to 73.4 pg/ml and mean plasma testosterone rose from 492 ng/100 ml to 971 ng/100 ml in the normal men; no steroid changes were demonstrable in the "agonadal" group. Additionally, the concomitant administration of clomiphene with hCG prevented the hCG induced FSH suppression in 3 normal men. FSH suppression during shortterm hCG administration to normal men is probably due to negative feedback by testicular steroids.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical