Abstract
Plasma and urinary follicle stimuulating hormone, plasma estradiol, and plasma testosterone were measured prior to and after a 4-day hCG provocative test (4000 IU/day) in 6 normal men and in 5 patients with deficient gonadal steroidogenesis ("agonadal"). Plasma and urinary FSH decreased significantly (p < .01) after hCG treatment in the normal men but did not change in the "agonadal" subjects. Mean plasma estradiol rose from 33.4 pg/ml to 73.4 pg/ml and mean plasma testosterone rose from 492 ng/100 ml to 971 ng/100 ml in the normal men; no steroid changes were demonstrable in the "agonadal" group. Additionally, the concomitant administration of clomiphene with hCG prevented the hCG induced FSH suppression in 3 normal men. FSH suppression during shortterm hCG administration to normal men is probably due to negative feedback by testicular steroids.
Original language | English (US) |
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Pages (from-to) | 1080-1084 |
Number of pages | 5 |
Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 34 |
Issue number | 6 |
DOIs | |
State | Published - 1972 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical