Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women

Zakia Coriaty Nelson, Roberta M. Ray, Chunyuan Wu, Helge Stalsberg, Peggy Porter, Johanna W. Lampe, Jackilen (Jackie) Shannon, Neilann Horner, Wenjin Li, Wenwan Wang, Yongwei Hu, Daoli Gao, David B. Thomas

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Fibroadenomas are common benign breast conditions among women and account for ∼50% of breast biopsies performed. Dietary factors are known to influence benign breast conditions in the aggregate, but little is known of their association specifically with fibroadenoma. Our objective in this study was to evaluate the association between dietary and other factors and fibroadenoma risk. A case-control study, nested in a randomized trial of breast self-examination (BSE) in Chinese textile workers in Shanghai, China, was conducted between 1989 and 2000. The study sample included 327 affected women and 1070 controls. Women were administered a FFQ and a questionnaire that elicited reproductive and gynecological history and other information. Odds ratios, as estimates of relative risks, were calculated using multivariate conditional logistic regression. Significant decreasing trends in risk of fibroadenoma were observed with intake of fruits and vegetables and with number of live births, and a reduced risk was also associated with natural menopause, oral contraceptive use, and moderate exercise (walking and gardening). Increased risk of fibroadenoma was associated with heavy physical activity in one's 20s, breast cancer in a first-degree relative, and a history of prior benign breast lumps; and significant increasing trends in risk were observed with numbers of BSE per year and years of education. In conclusion, a diet rich in fruits and vegetables and the use of oral contraceptives may reduce risk of fibroadenoma.

Original languageEnglish (US)
Pages (from-to)1294-1301
Number of pages8
JournalJournal of Nutrition
Volume140
Issue number7
DOIs
StatePublished - Jul 2010

Fingerprint

Fibroadenoma
Vegetables
Fruit
Breast
Breast Self-Examination
Oral Contraceptives
Gardening
Exercise
Reproductive History
Textiles
Live Birth
Menopause
Walking
Case-Control Studies
China
Logistic Models
Odds Ratio
Breast Neoplasms
Diet
Biopsy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Nelson, Z. C., Ray, R. M., Wu, C., Stalsberg, H., Porter, P., Lampe, J. W., ... Thomas, D. B. (2010). Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women. Journal of Nutrition, 140(7), 1294-1301. https://doi.org/10.3945/jn.109.119719

Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women. / Nelson, Zakia Coriaty; Ray, Roberta M.; Wu, Chunyuan; Stalsberg, Helge; Porter, Peggy; Lampe, Johanna W.; Shannon, Jackilen (Jackie); Horner, Neilann; Li, Wenjin; Wang, Wenwan; Hu, Yongwei; Gao, Daoli; Thomas, David B.

In: Journal of Nutrition, Vol. 140, No. 7, 07.2010, p. 1294-1301.

Research output: Contribution to journalArticle

Nelson, ZC, Ray, RM, Wu, C, Stalsberg, H, Porter, P, Lampe, JW, Shannon, JJ, Horner, N, Li, W, Wang, W, Hu, Y, Gao, D & Thomas, DB 2010, 'Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women', Journal of Nutrition, vol. 140, no. 7, pp. 1294-1301. https://doi.org/10.3945/jn.109.119719
Nelson, Zakia Coriaty ; Ray, Roberta M. ; Wu, Chunyuan ; Stalsberg, Helge ; Porter, Peggy ; Lampe, Johanna W. ; Shannon, Jackilen (Jackie) ; Horner, Neilann ; Li, Wenjin ; Wang, Wenwan ; Hu, Yongwei ; Gao, Daoli ; Thomas, David B. / Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women. In: Journal of Nutrition. 2010 ; Vol. 140, No. 7. pp. 1294-1301.
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