From the archives of the AFIP: A comprehensive review of fetal tumors with pathologic correlation

Paula J. Woodward, Roya Sohaey, Anne Kennedy, Kelly K. Koeller

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Fetal tumors are a diverse group of neoplasms, which are unique in their histologic characteristics, anatomic distribution, and pathophysiology. The biologic behavior of tumors in the fetus may differ dramatically compared with that of the same tumor detected later in life. Teratomas are the dominant histologic type and constitute the majority of both extracranial and intracranial neoplasms. Although often histologically mature, they may prove lethal because of their location and metabolic demands on the fetus. Large solid tumors may lead to cardiovascular compromise and hydrops fetalis. Extracranial teratomas are most commonly located in the sacrococcygeal area, followed by the head and neck, chest, and retroperitoneum. Fetuses with intracranial tumors have a poor prognosis regardless of histologic type. There are, however, two notable exceptions: lipomas and choroid plexus papillomas, both of which have a more favorable outcome. Neuroblastoma is the most common fetal malignancy. It may be either solid or cystic and is more often located on the right side. It typically has favorable biologic markers and stage at presentation. The prognosis for prenatally diagnosed cases is excellent. Other fetal neoplasms include soft-tissue tumors (both benign and malignant), leukemia, mesenchymal hamartoma of the kidney, and liver tumors (hemangioendothelioma, mesenchymal hamartoma, and hepatoblastoma).

Original languageEnglish (US)
Pages (from-to)215-242
Number of pages28
JournalRadiographics
Volume25
Issue number1
StatePublished - Jan 2005

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Neoplasms
Fetus
Hamartoma
Teratoma
Choroid Plexus Papilloma
Soft Tissue Neoplasms
Hemangioendothelioma
Hepatoblastoma
Hydrops Fetalis
Lipoma
Neuroblastoma
Brain Neoplasms
Leukemia
Neck
Thorax
Biomarkers
Head
Kidney
Liver

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

From the archives of the AFIP : A comprehensive review of fetal tumors with pathologic correlation. / Woodward, Paula J.; Sohaey, Roya; Kennedy, Anne; Koeller, Kelly K.

In: Radiographics, Vol. 25, No. 1, 01.2005, p. 215-242.

Research output: Contribution to journalArticle

Woodward, Paula J. ; Sohaey, Roya ; Kennedy, Anne ; Koeller, Kelly K. / From the archives of the AFIP : A comprehensive review of fetal tumors with pathologic correlation. In: Radiographics. 2005 ; Vol. 25, No. 1. pp. 215-242.
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