From Reductionism to Reintegration: Solving society's most pressing problems requires building bridges between data types across the life sciences

Anne E. Thessen, Paul Bogdan, David J. Patterson, Theresa M. Casey, César Hinojo-Hinojo, Orlando de Lange, Melissa A. Haendel

Research output: Contribution to journalArticlepeer-review

Abstract

Decades of reductionist approaches in biology have achieved spectacular progress, but the proliferation of subdisciplines, each with its own technical and social practices regarding data, impedes the growth of the multidisciplinary and interdisciplinary approaches now needed to address pressing societal challenges. Data integration is key to a reintegrated biology able to address global issues such as climate change, biodiversity loss, and sustainable ecosystem management. We identify major challenges to data integration and present a vision for a "Data as a Service"-oriented architecture to promote reuse of data for discovery. The proposed architecture includes standards development, new tools and services, and strategies for career-development and sustainability.

Original languageEnglish (US)
Pages (from-to)e3001129
JournalPLoS Biology
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2021

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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