From behavior to molecules: an integrated approach to the study of neuropeptides

N. Tublitz, D. Brink, K. S. Broadie, P. K. Loi, Andrew Sylwester

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta, provide an opportunity to elucidate these links. The CAPs are involved in the modulation of four distinct types of behavior during the life cycle of this moth. Functional differences at these four developmental periods can be explained by stage-specific changes in target sensitivity and the distribution of the CAP-containing neurons, including a set of peptidergic neurons that alter their transmitter phenotype post-embryonically. Studies show that inositol 1,4,5-triphosphate (IP3), linked to intracellular Ca 2+, mediates the response of the cells to the CAPs. This preparation thus provides additional insights into the mechanisms underlying the action of multifunctional neuropeptides.

Original languageEnglish (US)
Pages (from-to)254-259
Number of pages6
JournalTrends in Neurosciences
Volume14
Issue number6
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Neuropeptides
Manduca
Neurons
Inositol 1,4,5-Trisphosphate
Neurobiology
Moths
Life Cycle Stages
Tobacco
Insects
Phenotype
Peptides
crustacean cardioactive peptide

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

From behavior to molecules : an integrated approach to the study of neuropeptides. / Tublitz, N.; Brink, D.; Broadie, K. S.; Loi, P. K.; Sylwester, Andrew.

In: Trends in Neurosciences, Vol. 14, No. 6, 1991, p. 254-259.

Research output: Contribution to journalArticle

Tublitz, N. ; Brink, D. ; Broadie, K. S. ; Loi, P. K. ; Sylwester, Andrew. / From behavior to molecules : an integrated approach to the study of neuropeptides. In: Trends in Neurosciences. 1991 ; Vol. 14, No. 6. pp. 254-259.
@article{59eb5a88cc6e43e796719e7394eae27a,
title = "From behavior to molecules: an integrated approach to the study of neuropeptides",
abstract = "Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta, provide an opportunity to elucidate these links. The CAPs are involved in the modulation of four distinct types of behavior during the life cycle of this moth. Functional differences at these four developmental periods can be explained by stage-specific changes in target sensitivity and the distribution of the CAP-containing neurons, including a set of peptidergic neurons that alter their transmitter phenotype post-embryonically. Studies show that inositol 1,4,5-triphosphate (IP3), linked to intracellular Ca 2+, mediates the response of the cells to the CAPs. This preparation thus provides additional insights into the mechanisms underlying the action of multifunctional neuropeptides.",
author = "N. Tublitz and D. Brink and Broadie, {K. S.} and Loi, {P. K.} and Andrew Sylwester",
year = "1991",
doi = "10.1016/0166-2236(91)90126-F",
language = "English (US)",
volume = "14",
pages = "254--259",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - From behavior to molecules

T2 - an integrated approach to the study of neuropeptides

AU - Tublitz, N.

AU - Brink, D.

AU - Broadie, K. S.

AU - Loi, P. K.

AU - Sylwester, Andrew

PY - 1991

Y1 - 1991

N2 - Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta, provide an opportunity to elucidate these links. The CAPs are involved in the modulation of four distinct types of behavior during the life cycle of this moth. Functional differences at these four developmental periods can be explained by stage-specific changes in target sensitivity and the distribution of the CAP-containing neurons, including a set of peptidergic neurons that alter their transmitter phenotype post-embryonically. Studies show that inositol 1,4,5-triphosphate (IP3), linked to intracellular Ca 2+, mediates the response of the cells to the CAPs. This preparation thus provides additional insights into the mechanisms underlying the action of multifunctional neuropeptides.

AB - Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta, provide an opportunity to elucidate these links. The CAPs are involved in the modulation of four distinct types of behavior during the life cycle of this moth. Functional differences at these four developmental periods can be explained by stage-specific changes in target sensitivity and the distribution of the CAP-containing neurons, including a set of peptidergic neurons that alter their transmitter phenotype post-embryonically. Studies show that inositol 1,4,5-triphosphate (IP3), linked to intracellular Ca 2+, mediates the response of the cells to the CAPs. This preparation thus provides additional insights into the mechanisms underlying the action of multifunctional neuropeptides.

UR - http://www.scopus.com/inward/record.url?scp=0025884464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025884464&partnerID=8YFLogxK

U2 - 10.1016/0166-2236(91)90126-F

DO - 10.1016/0166-2236(91)90126-F

M3 - Article

C2 - 1716020

AN - SCOPUS:0025884464

VL - 14

SP - 254

EP - 259

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 6

ER -