TY - JOUR
T1 - From behavior to molecules
T2 - an integrated approach to the study of neuropeptides
AU - Tublitz, N.
AU - Brink, D.
AU - Broadie, K. S.
AU - Loi, P. K.
AU - Sylwester, A. W.
N1 - Funding Information:
manuscript. This work review of the Springer-Verlag was supported by de Zeeuw, C. I., Holstege, J. C., Ruigrok, T. J. H. and Voogd, NIH Grants NS18242 J. (1989) in The Olivocerebellar System in Motor Control and N523209. McCollum, G. and Robertson, L. T. (1987) Soc. (Strata, P., ed.), pp. 111-116, Springer-Verlag Abstr. 13, 602 30 Bell, C. C. and Kawasaki, T. (1972) J. Neurophysiol. 35, 155--169 31 Llinb,s , R. and Yarom, Y. (1981) J. PhysioL 315, 569-584 32 Bishop, G. A., Blake, T. L. and O'Donoghue, D. L. (1987) in New Concepts in Cerebellar Neurobiology (King, J. S., ed.), pp. 29-56, Alan R. Liss
PY - 1991/6
Y1 - 1991/6
N2 - Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta, provide an opportunity to elucidate these links. The CAPs are involved in the modulation of four distinct types of behavior during the life cycle of this moth. Functional differences at these four developmental periods can be explained by stage-specific changes in target sensitivity and the distribution of the CAP-containing neurons, including a set of peptidergic neurons that alter their transmitter phenotype post-embryonically. Studies show that inositol 1,4,5-triphosphate (IP3), linked to intracellular Ca 2+, mediates the response of the cells to the CAPs. This preparation thus provides additional insights into the mechanisms underlying the action of multifunctional neuropeptides.
AB - Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta, provide an opportunity to elucidate these links. The CAPs are involved in the modulation of four distinct types of behavior during the life cycle of this moth. Functional differences at these four developmental periods can be explained by stage-specific changes in target sensitivity and the distribution of the CAP-containing neurons, including a set of peptidergic neurons that alter their transmitter phenotype post-embryonically. Studies show that inositol 1,4,5-triphosphate (IP3), linked to intracellular Ca 2+, mediates the response of the cells to the CAPs. This preparation thus provides additional insights into the mechanisms underlying the action of multifunctional neuropeptides.
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U2 - 10.1016/0166-2236(91)90126-F
DO - 10.1016/0166-2236(91)90126-F
M3 - Article
C2 - 1716020
AN - SCOPUS:0025884464
SN - 0166-2236
VL - 14
SP - 254
EP - 259
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 6
ER -