Frequent Novel DNA Copy Number Increase in Squamous Cell Head and Neck Tumors

Pius M. Brzoska, Nikki A. Levin, Karen K. Fu, Michael J. Kaplan, Mark I. Singer, Joe W. Gray, Michael F. Christman

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

We have undertaken a study of DNA copy number changes in head and neck squamous cell carcinomas to identify novel DNA copy number changes and to determine the significance of previous findings of cytogenetic alterations in cultured cells. Comparative genomic hybridization was performed on genomic DNA extracted from ten tumors. A novel copy number gain on chromosome 3q26-27 and a loss of chromosome 3p were found at high frequency (≥50% of tumors). Many other novel chromosomal copy number changes were identified but occurred at a lower frequency. In addition, our data confirm that DNA copy number changes that frequently occur in cultured cells, such as loss of chromosome 3p, also occur in tumors. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in head and neck squamous cell carcinoma tumorigenesis.

Original languageEnglish (US)
Pages (from-to)3055-3059
Number of pages5
JournalCancer Research
Volume55
Issue number14
StatePublished - Jul 15 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Brzoska, P. M., Levin, N. A., Fu, K. K., Kaplan, M. J., Singer, M. I., Gray, J. W., & Christman, M. F. (1995). Frequent Novel DNA Copy Number Increase in Squamous Cell Head and Neck Tumors. Cancer Research, 55(14), 3055-3059.