Frequent novel DNA copy number increase in squamous cell head and neck tumors

P. M. Brzoska, N. A. Levin, K. K. Fu, M. J. Kaplan, M. I. Singer, Joe Gray, M. F. Christman

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

We have undertaken a study of DNA copy number changes in head and neck squamous cell carcinomas to identify novel DNA copy number changes and to determine the significance of previous findings of cytogenetic alterations in cultured cells. Comparative genomic hybridization was performed on genomic DNA extracted from ten tumors. A novel copy number gain on chromosome 3q26- 27 and a loss of chromosome 3p were found at high frequency (≥50% of tumors). Many other novel chromosomal copy number changes were identified but occurred at a lower frequency. In addition, our data confirm that DNA copy number changes that frequently occur in cultured cells, such as loss of chromosome 3p, also occur in tumors. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in head and neck squamous cell carcinoma tumorigenesis.

Original languageEnglish (US)
Pages (from-to)3055-3059
Number of pages5
JournalCancer Research
Volume55
Issue number14
StatePublished - 1995
Externally publishedYes

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DNA Copy Number Variations
Neck
Chromosomes
Epithelial Cells
Cultured Cells
DNA
Neoplasms
Comparative Genomic Hybridization
Tumor Suppressor Genes
Oncogenes
Cytogenetics
Carcinogenesis
Carcinoma, squamous cell of head and neck

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Brzoska, P. M., Levin, N. A., Fu, K. K., Kaplan, M. J., Singer, M. I., Gray, J., & Christman, M. F. (1995). Frequent novel DNA copy number increase in squamous cell head and neck tumors. Cancer Research, 55(14), 3055-3059.

Frequent novel DNA copy number increase in squamous cell head and neck tumors. / Brzoska, P. M.; Levin, N. A.; Fu, K. K.; Kaplan, M. J.; Singer, M. I.; Gray, Joe; Christman, M. F.

In: Cancer Research, Vol. 55, No. 14, 1995, p. 3055-3059.

Research output: Contribution to journalArticle

Brzoska, PM, Levin, NA, Fu, KK, Kaplan, MJ, Singer, MI, Gray, J & Christman, MF 1995, 'Frequent novel DNA copy number increase in squamous cell head and neck tumors', Cancer Research, vol. 55, no. 14, pp. 3055-3059.
Brzoska PM, Levin NA, Fu KK, Kaplan MJ, Singer MI, Gray J et al. Frequent novel DNA copy number increase in squamous cell head and neck tumors. Cancer Research. 1995;55(14):3055-3059.
Brzoska, P. M. ; Levin, N. A. ; Fu, K. K. ; Kaplan, M. J. ; Singer, M. I. ; Gray, Joe ; Christman, M. F. / Frequent novel DNA copy number increase in squamous cell head and neck tumors. In: Cancer Research. 1995 ; Vol. 55, No. 14. pp. 3055-3059.
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