Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Joshua A. Sonnen, John C. Breitner, Mark A. Lovell, William R. Markesbery, Joseph F. Quinn, Thomas J. Montine

Research output: Contribution to journalReview article

87 Scopus citations

Abstract

Advances in our understanding of the etiologies and pathogenesis of Alzheimer's disease (AD) highlight a role for free radical-mediated injury to brain regions from early stages of this illness. Here we will review the evidence from transgenic mouse models of AD, autopsy samples, and human biofluids obtained during life paying particular attention to the stage of disease. In addition, we will review the epidemiologic literature that addresses the potential of anti-oxidants to prevent incident dementia from AD, and the clinical trial literature that addresses anti-oxidant preventative or therapeutic strategies for different stage of AD. Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD.

Original languageEnglish (US)
Pages (from-to)219-230
Number of pages12
JournalFree Radical Biology and Medicine
Volume45
Issue number3
DOIs
StatePublished - Aug 1 2008

Keywords

  • Alzheimer's disease
  • Anti-oxidants
  • Mild Cognitive Impairement
  • Oxidative damage

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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