Free radical damage to cerebral cortex in alzheimer's disease, microvascular brain injury, and smoking

Joshua A. Sonnen, Eric B. Larson, Shelly L. Gray, Angela Wilson, Steven G. Kohama, Paul K. Crane, John C.S. Breitner, Thomas J. Montine

    Research output: Contribution to journalArticle

    38 Scopus citations

    Abstract

    Evidence supports a pathogenic role for free radical injury to brain in Alzheimer's disease; however, clinical trial results are only mildly encouraging. Examining brains from The Adult Changes in Thought study offers a unique perspective. Selectively increased free radical damage to cerebral cortex was associated with Alzheimer's disease, microvascular brain injury, and current smoking, but not with antioxidant supplement usage. Our results support suppression of free radical injury to brain as a therapeutic target for Alzheimer's disease and microvascular brain injury; however, future clinical trials should considet other antioxidants or doses than those identified in our study.

    Original languageEnglish (US)
    Pages (from-to)226-229
    Number of pages4
    JournalAnnals of Neurology
    Volume65
    Issue number2
    DOIs
    StatePublished - Feb 1 2009

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

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  • Cite this

    Sonnen, J. A., Larson, E. B., Gray, S. L., Wilson, A., Kohama, S. G., Crane, P. K., Breitner, J. C. S., & Montine, T. J. (2009). Free radical damage to cerebral cortex in alzheimer's disease, microvascular brain injury, and smoking. Annals of Neurology, 65(2), 226-229. https://doi.org/10.1002/ana.21508