Free HIV Antiretroviral Therapy Enhances Adherence among Individuals on Stable Treatment: Implications for Potential Shortfalls in Free Antiretroviral Therapy

Jayne Byakika-Tusiime, Eric C. Polley, Jessica H. Oyugi, David Bangsberg

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective:To estimate the population-level causal effect of source of payment for HIV medication on treatment adherence using Marginal Structural Models.Methods:Data were obtained from an observational cohort of 76 HIV-infected individuals with at least 24 weeks of antiretroviral therapy treatment from 2002 to 2007 in Kampala, Uganda. Adherence was the primary outcome and it was measured using the 30-day visual analogue scale. Marginal structural models (MSM) were used to estimate the effect of source of payment for HIV medication on adherence, adjusting for confounding by income, duration on antiretroviral therapy (ART), timing of visit, prior adherence, prior CD4+ T cell count and prior plasma HIV RNA. Traditional association models were also examined and the results compared.Results:Free HIV treatment was associated with a 3.8% improvement in adherence in the marginal structural model, while the traditional statistical models showed a 3.1-3.3% improvement in adherence associated with free HIV treatment. Conclusion:Removing a financial barrier to treatment with ART by providing free HIV treatment appears to significantly improve adherence to antiretroviral therapy. With sufficient information on confounders, MSMs can be used to make robust inferences about causal effects in epidemiologic research.

Original languageEnglish (US)
Article numbere70375
JournalPLoS One
Volume8
Issue number9
DOIs
StatePublished - Sep 5 2013
Externally publishedYes

Fingerprint

HIV
therapeutics
Structural Models
drug therapy
T-cells
Therapeutics
Uganda
statistical models
income
T-lymphocytes
RNA
Medication Adherence
Plasmas
Statistical Models
CD4 Lymphocyte Count
duration
Visual Analog Scale
T-Lymphocytes
Research
Population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Free HIV Antiretroviral Therapy Enhances Adherence among Individuals on Stable Treatment : Implications for Potential Shortfalls in Free Antiretroviral Therapy. / Byakika-Tusiime, Jayne; Polley, Eric C.; Oyugi, Jessica H.; Bangsberg, David.

In: PLoS One, Vol. 8, No. 9, e70375, 05.09.2013.

Research output: Contribution to journalArticle

@article{7a4abfea07d640ccb378ff268469d93b,
title = "Free HIV Antiretroviral Therapy Enhances Adherence among Individuals on Stable Treatment: Implications for Potential Shortfalls in Free Antiretroviral Therapy",
abstract = "Objective:To estimate the population-level causal effect of source of payment for HIV medication on treatment adherence using Marginal Structural Models.Methods:Data were obtained from an observational cohort of 76 HIV-infected individuals with at least 24 weeks of antiretroviral therapy treatment from 2002 to 2007 in Kampala, Uganda. Adherence was the primary outcome and it was measured using the 30-day visual analogue scale. Marginal structural models (MSM) were used to estimate the effect of source of payment for HIV medication on adherence, adjusting for confounding by income, duration on antiretroviral therapy (ART), timing of visit, prior adherence, prior CD4+ T cell count and prior plasma HIV RNA. Traditional association models were also examined and the results compared.Results:Free HIV treatment was associated with a 3.8{\%} improvement in adherence in the marginal structural model, while the traditional statistical models showed a 3.1-3.3{\%} improvement in adherence associated with free HIV treatment. Conclusion:Removing a financial barrier to treatment with ART by providing free HIV treatment appears to significantly improve adherence to antiretroviral therapy. With sufficient information on confounders, MSMs can be used to make robust inferences about causal effects in epidemiologic research.",
author = "Jayne Byakika-Tusiime and Polley, {Eric C.} and Oyugi, {Jessica H.} and David Bangsberg",
year = "2013",
month = "9",
day = "5",
doi = "10.1371/journal.pone.0070375",
language = "English (US)",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

TY - JOUR

T1 - Free HIV Antiretroviral Therapy Enhances Adherence among Individuals on Stable Treatment

T2 - Implications for Potential Shortfalls in Free Antiretroviral Therapy

AU - Byakika-Tusiime, Jayne

AU - Polley, Eric C.

AU - Oyugi, Jessica H.

AU - Bangsberg, David

PY - 2013/9/5

Y1 - 2013/9/5

N2 - Objective:To estimate the population-level causal effect of source of payment for HIV medication on treatment adherence using Marginal Structural Models.Methods:Data were obtained from an observational cohort of 76 HIV-infected individuals with at least 24 weeks of antiretroviral therapy treatment from 2002 to 2007 in Kampala, Uganda. Adherence was the primary outcome and it was measured using the 30-day visual analogue scale. Marginal structural models (MSM) were used to estimate the effect of source of payment for HIV medication on adherence, adjusting for confounding by income, duration on antiretroviral therapy (ART), timing of visit, prior adherence, prior CD4+ T cell count and prior plasma HIV RNA. Traditional association models were also examined and the results compared.Results:Free HIV treatment was associated with a 3.8% improvement in adherence in the marginal structural model, while the traditional statistical models showed a 3.1-3.3% improvement in adherence associated with free HIV treatment. Conclusion:Removing a financial barrier to treatment with ART by providing free HIV treatment appears to significantly improve adherence to antiretroviral therapy. With sufficient information on confounders, MSMs can be used to make robust inferences about causal effects in epidemiologic research.

AB - Objective:To estimate the population-level causal effect of source of payment for HIV medication on treatment adherence using Marginal Structural Models.Methods:Data were obtained from an observational cohort of 76 HIV-infected individuals with at least 24 weeks of antiretroviral therapy treatment from 2002 to 2007 in Kampala, Uganda. Adherence was the primary outcome and it was measured using the 30-day visual analogue scale. Marginal structural models (MSM) were used to estimate the effect of source of payment for HIV medication on adherence, adjusting for confounding by income, duration on antiretroviral therapy (ART), timing of visit, prior adherence, prior CD4+ T cell count and prior plasma HIV RNA. Traditional association models were also examined and the results compared.Results:Free HIV treatment was associated with a 3.8% improvement in adherence in the marginal structural model, while the traditional statistical models showed a 3.1-3.3% improvement in adherence associated with free HIV treatment. Conclusion:Removing a financial barrier to treatment with ART by providing free HIV treatment appears to significantly improve adherence to antiretroviral therapy. With sufficient information on confounders, MSMs can be used to make robust inferences about causal effects in epidemiologic research.

UR - http://www.scopus.com/inward/record.url?scp=84883499664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883499664&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0070375

DO - 10.1371/journal.pone.0070375

M3 - Article

C2 - 24039704

AN - SCOPUS:84883499664

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 9

M1 - e70375

ER -