Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Human cytomegalovirus UL54 DNA polymerase gene mutations that confer foscarnet resistance in clinical practice typically cluster in the amino terminal 2, palm and finger domains. Exposure to foscarnet in cell culture selected for mutations elsewhere in UL54, including amino acid substitutions S290R in the amino terminal 1 domain and E951D in the palm 2 domain. These are newly confirmed to confer foscarnet resistance and slightly decreased ganciclovir susceptibility. Other emergent substitutions N495K, T552N and T838A are known to confer foscarnet resistance, while additional ones Q783R and V798A only slightly affected susceptibility. An expanded set of domains is involved in foscarnet resistance and its genotypic diagnosis.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalAntiviral Research
Volume138
DOIs
StatePublished - Feb 1 2017

Fingerprint

Foscarnet
DNA-Directed DNA Polymerase
Cytomegalovirus
Mutation
Genes
Ganciclovir
Amino Acid Substitution
Fingers
Cell Culture Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Virology

Cite this

Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene. / Chou, Sunwen.

In: Antiviral Research, Vol. 138, 01.02.2017, p. 57-60.

Research output: Contribution to journalArticle

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