Forward-looking intracardiac imaging catheters using fully integrated CMUT arrays

Amin Nikoozadeh, Ömer Oralkan, Mustafa Gencel, Jung Woo Choe, Douglas N. Stephens, Alan De La Rama, Peter Chen, Feng Lin, Aaron Dentinger, Douglas Wildes, Kai Thomenius, Kalyanam Shivkumar, Aman Mahajan, Chi Hyung Seo, Matthew O'Donnell, Uyen Truong, David Sahn, Pierre T. Khuri-Yakub

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Citations (Scopus)

Abstract

Atrial fibrillation, the most common type of cardiac arrhythmia, now affects more than 2.2 million adults in the US alone. Currently, electrophysiological interventions are performed under fluoroscopy guidance, which besides its harmful ionizing radiation does not provide adequate soft-tissue resolution. Intracardiac echocardiography (ICE) provides realtime anatomical information that has proven valuable in reducing the fluoroscopy time and enhancing procedural success. We developed two types of forward-looking ICE catheters using capacitive micromachined ultrasonic transducer (CMUT) technology: MicroLinear (ML) and ring catheters. The ML catheter enables real-time forward-looking 2-D imaging using a 24-element 1-D CMUT phased-array that is designed for a center frequency of 10 MHz. The ring catheter uses a 64-element ring CMUT array that is also designed for a center frequency of 10 MHz. However, this ring-shaped 2-D array enables real-time forward-looking volumetric imaging. In addition, this catheter provides a continuous central lumen that enables convenient delivery of other devices such as RF ablation catheter, EP diagnostic catheter, biopsy devices, etc. Both catheters are equipped with custom front-end IC's that are integrated with the CMUT arrays at the tip of the catheters. The integration of the IC's with the CMUT arrays was accomplished using custom flexible PCB's. We also developed several image reconstruction schemes for the ring catheter on a PC-based imaging platform from VeraSonics. We performed a variety of bench-top characterizations to validate the functionality and performance of our fully integrated CMUT arrays. Using both catheters, we demonstrated in vivo images of the heart in a porcine animal model. We have successfully prototyped the first CMUT-based ICE catheters and proven the capabilities of the CMUT technology for implementing high-frequency miniature transducer arrays with integrated electronics.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages770-773
Number of pages4
DOIs
StatePublished - 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Other

Other2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

Fingerprint

transducers
ultrasonics
echocardiography
rings
fluoroscopy
arrhythmia
fibrillation
animal models
lumens
polychlorinated biphenyls
phased arrays
image reconstruction
ionizing radiation
seats
ablation
delivery
platforms
electronics

Keywords

  • capacitive micromachined ultrasonic transducers
  • CMUT
  • electrophysiology
  • forward-looking
  • intracardiac echocardiography
  • real-time
  • ultrasound
  • volumetric

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Nikoozadeh, A., Oralkan, Ö., Gencel, M., Choe, J. W., Stephens, D. N., De La Rama, A., ... Khuri-Yakub, P. T. (2010). Forward-looking intracardiac imaging catheters using fully integrated CMUT arrays. In Proceedings - IEEE Ultrasonics Symposium (pp. 770-773). [5935817] https://doi.org/10.1109/ULTSYM.2010.5935817

Forward-looking intracardiac imaging catheters using fully integrated CMUT arrays. / Nikoozadeh, Amin; Oralkan, Ömer; Gencel, Mustafa; Choe, Jung Woo; Stephens, Douglas N.; De La Rama, Alan; Chen, Peter; Lin, Feng; Dentinger, Aaron; Wildes, Douglas; Thomenius, Kai; Shivkumar, Kalyanam; Mahajan, Aman; Seo, Chi Hyung; O'Donnell, Matthew; Truong, Uyen; Sahn, David; Khuri-Yakub, Pierre T.

Proceedings - IEEE Ultrasonics Symposium. 2010. p. 770-773 5935817.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nikoozadeh, A, Oralkan, Ö, Gencel, M, Choe, JW, Stephens, DN, De La Rama, A, Chen, P, Lin, F, Dentinger, A, Wildes, D, Thomenius, K, Shivkumar, K, Mahajan, A, Seo, CH, O'Donnell, M, Truong, U, Sahn, D & Khuri-Yakub, PT 2010, Forward-looking intracardiac imaging catheters using fully integrated CMUT arrays. in Proceedings - IEEE Ultrasonics Symposium., 5935817, pp. 770-773, 2010 IEEE International Ultrasonics Symposium, IUS 2010, San Diego, CA, United States, 10/11/10. https://doi.org/10.1109/ULTSYM.2010.5935817
Nikoozadeh A, Oralkan Ö, Gencel M, Choe JW, Stephens DN, De La Rama A et al. Forward-looking intracardiac imaging catheters using fully integrated CMUT arrays. In Proceedings - IEEE Ultrasonics Symposium. 2010. p. 770-773. 5935817 https://doi.org/10.1109/ULTSYM.2010.5935817
Nikoozadeh, Amin ; Oralkan, Ömer ; Gencel, Mustafa ; Choe, Jung Woo ; Stephens, Douglas N. ; De La Rama, Alan ; Chen, Peter ; Lin, Feng ; Dentinger, Aaron ; Wildes, Douglas ; Thomenius, Kai ; Shivkumar, Kalyanam ; Mahajan, Aman ; Seo, Chi Hyung ; O'Donnell, Matthew ; Truong, Uyen ; Sahn, David ; Khuri-Yakub, Pierre T. / Forward-looking intracardiac imaging catheters using fully integrated CMUT arrays. Proceedings - IEEE Ultrasonics Symposium. 2010. pp. 770-773
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