Abstract
A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400 nM and selective for μ-opioid receptors.
Original language | English (US) |
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Pages (from-to) | 6580-6582 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 22 |
Issue number | 21 |
DOIs | |
State | Published - Nov 1 2012 |
Keywords
- Formylated amines
- Peptide mimetic
- Peptides
- Polyamine
- Retro-inverso peptide
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry