Formylated polyamines as peptidomimetics

Sacha Javor, Aaron Janowsky, Robert Johnson, Katherine Wolfrum, Mitra Tadayoni-Rebek, Julius Rebek

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A new construct for imitating a natural peptide ligand using a modified retro-inverso sequence is described. It is demonstrated through the synthesis of a peptidomimetic derived from the endogenous sequence of leucine enkephalin. The product was active at 400 nM and selective for μ-opioid receptors.

Original languageEnglish (US)
Pages (from-to)6580-6582
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number21
DOIs
StatePublished - Nov 1 2012

Keywords

  • Formylated amines
  • Peptide mimetic
  • Peptides
  • Polyamine
  • Retro-inverso peptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Formylated polyamines as peptidomimetics'. Together they form a unique fingerprint.

  • Cite this

    Javor, S., Janowsky, A., Johnson, R., Wolfrum, K., Tadayoni-Rebek, M., & Rebek, J. (2012). Formylated polyamines as peptidomimetics. Bioorganic and Medicinal Chemistry Letters, 22(21), 6580-6582. https://doi.org/10.1016/j.bmcl.2012.09.008