Formation of methylation patterns in the mammalian genome

Mitchell S. Turker, Timothy H. Bestor

Research output: Contribution to journalReview article

104 Scopus citations

Abstract

Cytosine methylation in mammals is an epigenetic modification required for viability of the developing embryo. It has been suggested that DNA methylation plays important roles in X-chromosome inactivation, imprinting, protection of the genome from invasive DNA sequences, and compartmentalization of the genome into active and condensed regions. Despite the significance of DNA methylation in mammalian cells, the mechanisms used to establish methylation patterns during development are not understood. This review will summarize the current state of knowledge about potential roles for cis-and trans-acting factors in the formation of methylation patterns in the mammalian genome.

Original languageEnglish (US)
Pages (from-to)119-130
Number of pages12
JournalMutation Research - Reviews in Mutation Research
Volume386
Issue number2
DOIs
StatePublished - Apr 1997

Keywords

  • Mamalian genome
  • Methylation pattern

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis

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