Formation of methylation patterns in the mammalian genome

Mitchell S. Turker; Timothy H. Bestor

doi:10.1016/S1383-5742(96)00048-8

Formation of methylation patterns in the mammalian genome

Mitchell S. Turker, Timothy H. Bestor

Oregon Institute of Occupational Health Sciences

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

Abstract

Cytosine methylation in mammals is an epigenetic modification required for viability of the developing embryo. It has been suggested that DNA methylation plays important roles in X-chromosome inactivation, imprinting, protection of the genome from invasive DNA sequences, and compartmentalization of the genome into active and condensed regions. Despite the significance of DNA methylation in mammalian cells, the mechanisms used to establish methylation patterns during development are not understood. This review will summarize the current state of knowledge about potential roles for cis-and trans-acting factors in the formation of methylation patterns in the mammalian genome.

Original language	English (US)
Pages (from-to)	119-130
Number of pages	12
Journal	Mutation Research - Reviews in Mutation Research
Volume	386
Issue number	2
DOIs	https://doi.org/10.1016/S1383-5742(96)00048-8
State	Published - Apr 1997

Keywords

Mamalian genome
Methylation pattern

ASJC Scopus subject areas

Genetics
Health, Toxicology and Mutagenesis

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10.1016/S1383-5742(96)00048-8

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title = "Formation of methylation patterns in the mammalian genome",

abstract = "Cytosine methylation in mammals is an epigenetic modification required for viability of the developing embryo. It has been suggested that DNA methylation plays important roles in X-chromosome inactivation, imprinting, protection of the genome from invasive DNA sequences, and compartmentalization of the genome into active and condensed regions. Despite the significance of DNA methylation in mammalian cells, the mechanisms used to establish methylation patterns during development are not understood. This review will summarize the current state of knowledge about potential roles for cis-and trans-acting factors in the formation of methylation patterns in the mammalian genome.",

keywords = "Mamalian genome, Methylation pattern",

author = "Turker, {Mitchell S.} and Bestor, {Timothy H.}",

note = "Funding Information: We thank Drs. M. Pieretti and J. Graff for critical readings of this manuscript. This work was supported by a grant from The Council for Tobacco Research (MST) and grants from NIH (THB).",

year = "1997",

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AU - Turker, Mitchell S.

AU - Bestor, Timothy H.

N1 - Funding Information: We thank Drs. M. Pieretti and J. Graff for critical readings of this manuscript. This work was supported by a grant from The Council for Tobacco Research (MST) and grants from NIH (THB).

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Y1 - 1997/4

N2 - Cytosine methylation in mammals is an epigenetic modification required for viability of the developing embryo. It has been suggested that DNA methylation plays important roles in X-chromosome inactivation, imprinting, protection of the genome from invasive DNA sequences, and compartmentalization of the genome into active and condensed regions. Despite the significance of DNA methylation in mammalian cells, the mechanisms used to establish methylation patterns during development are not understood. This review will summarize the current state of knowledge about potential roles for cis-and trans-acting factors in the formation of methylation patterns in the mammalian genome.

AB - Cytosine methylation in mammals is an epigenetic modification required for viability of the developing embryo. It has been suggested that DNA methylation plays important roles in X-chromosome inactivation, imprinting, protection of the genome from invasive DNA sequences, and compartmentalization of the genome into active and condensed regions. Despite the significance of DNA methylation in mammalian cells, the mechanisms used to establish methylation patterns during development are not understood. This review will summarize the current state of knowledge about potential roles for cis-and trans-acting factors in the formation of methylation patterns in the mammalian genome.

KW - Mamalian genome

KW - Methylation pattern

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Formation of methylation patterns in the mammalian genome

Abstract

Keywords

ASJC Scopus subject areas

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