Food allergy in infants with atopic dermatitis: Limitations of food-specific IgE measurements

Jonathan M. Spergel, Mark Boguniewicz, Lynda Schneider, Jon Hanifin, Amy S. Paller, Lawrence F. Eichenfield

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVES: Children with atopic dermatitis (AD) have a higher risk for development of food allergies. The objective of this study was to examine incidence of food allergy development in infants with AD and the predictive value of food-antigen-specific immunoglobulin E measurements. METHODS: This trial examined the long-term safety and efficacy of pimecrolimus cream 1% in >1000 infants (3-18 months) with mild-to-severe AD without a history of food allergy. Food allergy development was followed throughout a 36-month randomized double-blind phase followed by an open-label (OL) phase up to 33 months. Additionally, sIgE for cow's milk, egg white, peanut, wheat, seafood mix, and soybean was measured by ImmunoCAP at baseline, end of the double-blind phase, and end of OL phase. RESULTS: By the end of the OL phase, 15.9% of infants with AD developed at least 1 food allergy; allergy to peanut was most common (6.6%), followed by cow's milk (4.3%) and egg white (3.9%). Seafood, soybean, and wheat allergies were rare. Levels of sIgE for milk, egg, and peanut increased with severity of AD, as determined by Investigator's Global Assessment score. We assigned sIgE decision points for the 6 foods and tested their ability to predict definite food allergy in this population. Positive predictive values for published and newly developed sIgE decision points were low (

Original languageEnglish (US)
Pages (from-to)e1530-e1538
JournalPediatrics
Volume136
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Food Hypersensitivity
Atopic Dermatitis
Immunoglobulin E
Food
Seafood
Egg White
Milk
Soybeans
Wheat Hypersensitivity
Peanut Hypersensitivity
Aptitude
Child Development
Triticum
Ovum
Research Personnel
Safety
Antigens
Incidence
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Spergel, J. M., Boguniewicz, M., Schneider, L., Hanifin, J., Paller, A. S., & Eichenfield, L. F. (2015). Food allergy in infants with atopic dermatitis: Limitations of food-specific IgE measurements. Pediatrics, 136(6), e1530-e1538. https://doi.org/10.1542/peds.2015-1444

Food allergy in infants with atopic dermatitis : Limitations of food-specific IgE measurements. / Spergel, Jonathan M.; Boguniewicz, Mark; Schneider, Lynda; Hanifin, Jon; Paller, Amy S.; Eichenfield, Lawrence F.

In: Pediatrics, Vol. 136, No. 6, 01.12.2015, p. e1530-e1538.

Research output: Contribution to journalArticle

Spergel, JM, Boguniewicz, M, Schneider, L, Hanifin, J, Paller, AS & Eichenfield, LF 2015, 'Food allergy in infants with atopic dermatitis: Limitations of food-specific IgE measurements', Pediatrics, vol. 136, no. 6, pp. e1530-e1538. https://doi.org/10.1542/peds.2015-1444
Spergel JM, Boguniewicz M, Schneider L, Hanifin J, Paller AS, Eichenfield LF. Food allergy in infants with atopic dermatitis: Limitations of food-specific IgE measurements. Pediatrics. 2015 Dec 1;136(6):e1530-e1538. https://doi.org/10.1542/peds.2015-1444
Spergel, Jonathan M. ; Boguniewicz, Mark ; Schneider, Lynda ; Hanifin, Jon ; Paller, Amy S. ; Eichenfield, Lawrence F. / Food allergy in infants with atopic dermatitis : Limitations of food-specific IgE measurements. In: Pediatrics. 2015 ; Vol. 136, No. 6. pp. e1530-e1538.
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