Follicular dendritic cell contributions to HIV pathogenesis

Gregory F. Burton; Brandon F. Keele; Jacob D. Estes; Tyler C. Thacker; Suzanne Gartner

doi:10.1016/S1044-5323(02)00060-X

Follicular dendritic cell contributions to HIV pathogenesis

Gregory F. Burton, Brandon F. Keele, Jacob D. Estes, Tyler C. Thacker, Suzanne Gartner

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

Early after infection, large quantities of HIV are trapped on follicular dendritic cells (FDCs) thus establishing a potent reservoir of infectious virus adjacent to highly susceptible CD4-bearing T lymphocytes. Throughout much of the disease course, active HIV infection is largely confined to sites surrounding FDCs suggesting that this microenvironment is highly conducive to infection. FDCs maintain HIV infectivity and trapped virus can cause infection even in the presence of neutralizing antibody. FDCs also contribute signaling to the germinal center microenvironment that appears to increase HIV infection and replication. This article discusses these FDC contributions to HIV pathogenesis.

Original language	English (US)
Pages (from-to)	275-284
Number of pages	10
Journal	Seminars in Immunology
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/S1044-5323(02)00060-X
State	Published - Aug 2002
Externally published	Yes

Keywords

Follicular dendritic cells
Germinal centers
HIV reservoirs
Human immunodeficiency virus
Lymphoid tissues

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/S1044-5323(02)00060-X

Cite this

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title = "Follicular dendritic cell contributions to HIV pathogenesis",

abstract = "Early after infection, large quantities of HIV are trapped on follicular dendritic cells (FDCs) thus establishing a potent reservoir of infectious virus adjacent to highly susceptible CD4-bearing T lymphocytes. Throughout much of the disease course, active HIV infection is largely confined to sites surrounding FDCs suggesting that this microenvironment is highly conducive to infection. FDCs maintain HIV infectivity and trapped virus can cause infection even in the presence of neutralizing antibody. FDCs also contribute signaling to the germinal center microenvironment that appears to increase HIV infection and replication. This article discusses these FDC contributions to HIV pathogenesis.",

keywords = "Follicular dendritic cells, Germinal centers, HIV reservoirs, Human immunodeficiency virus, Lymphoid tissues",

author = "Burton, {Gregory F.} and Keele, {Brandon F.} and Estes, {Jacob D.} and Thacker, {Tyler C.} and Suzanne Gartner",

note = "Funding Information: We thank Dr Keith Crandall, Michael Redd and Emily Palenske for helpful discussions regarding this work, which was supported by grants from the National Institute of Allergy and Infectious Disease (AI32406 and AI39963).",

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AU - Burton, Gregory F.

AU - Keele, Brandon F.

AU - Estes, Jacob D.

AU - Thacker, Tyler C.

AU - Gartner, Suzanne

N1 - Funding Information: We thank Dr Keith Crandall, Michael Redd and Emily Palenske for helpful discussions regarding this work, which was supported by grants from the National Institute of Allergy and Infectious Disease (AI32406 and AI39963).

PY - 2002/8

Y1 - 2002/8

N2 - Early after infection, large quantities of HIV are trapped on follicular dendritic cells (FDCs) thus establishing a potent reservoir of infectious virus adjacent to highly susceptible CD4-bearing T lymphocytes. Throughout much of the disease course, active HIV infection is largely confined to sites surrounding FDCs suggesting that this microenvironment is highly conducive to infection. FDCs maintain HIV infectivity and trapped virus can cause infection even in the presence of neutralizing antibody. FDCs also contribute signaling to the germinal center microenvironment that appears to increase HIV infection and replication. This article discusses these FDC contributions to HIV pathogenesis.

AB - Early after infection, large quantities of HIV are trapped on follicular dendritic cells (FDCs) thus establishing a potent reservoir of infectious virus adjacent to highly susceptible CD4-bearing T lymphocytes. Throughout much of the disease course, active HIV infection is largely confined to sites surrounding FDCs suggesting that this microenvironment is highly conducive to infection. FDCs maintain HIV infectivity and trapped virus can cause infection even in the presence of neutralizing antibody. FDCs also contribute signaling to the germinal center microenvironment that appears to increase HIV infection and replication. This article discusses these FDC contributions to HIV pathogenesis.

KW - Follicular dendritic cells

KW - Germinal centers

KW - HIV reservoirs

KW - Human immunodeficiency virus

KW - Lymphoid tissues

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Follicular dendritic cell contributions to HIV pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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