Follicular CD4 T helper cells as a major HIV reservoir compartment: A molecular perspective

Malika Aid, Frank P. Dupuy, Eirini Moysi, Susan Moir, Elias K. Haddad, Jacob D. Estes, Rafick Pierre Sekaly, Constantinos Petrovas, Susan Pereira Ribeiro

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Effective antiretroviral therapy (ART) has prevented the progression to AIDS and reduced HIV-related morbidities and mortality for the majority of infected individuals. However, a lifelong administration of ART is necessary, placing an inordinate burden on individuals and public health systems. Therefore, discovering therapeutic regimens able to eradicate or functionally cure HIV infection is of great importance. ART interruption leads to viral rebound highlighting the establishment and maintenance of a latent viral reservoir compartment even under long-term treatment. Follicular helper CD4 T cells (TFH) have been reported as a major cell compartment contributing to viral persistence, consequent to their susceptibility to infection and ability to release replication-competent new virions. Here, we discuss the molecular profiles and potential mechanisms that support the role of TFH cells as one of the major HIV reservoirs.

Original languageEnglish (US)
Article number895
JournalFrontiers in immunology
Volume9
Issue numberJUN
DOIs
StatePublished - Jun 18 2018

Keywords

  • Cure
  • Gene expression
  • HIV
  • Lymph nodes
  • TFH cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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