Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease

William E. Balch, Ineke Braakman, Jeff Brodsky, Raymond Frizzell, William Guggino, Gergely L. Lukacs, Christopher Penland, Harvey Pollard, William Skach, Eric Sorscher, Philip Thomas

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
Original languageEnglish (US)
Title of host publicationProtein Misfolding Diseases
Subtitle of host publicationCurrent and Emerging Principles and Therapies
PublisherJohn Wiley and Sons
Pages425-452
Number of pages28
ISBN (Print)9780471799283
DOIs
StatePublished - Jul 2 2010

Keywords

  • CFTR folding, series of sequential steps - nascent polypeptide, targeted to endoplasmic reticulum (ER)
  • Cystic fibrosis folding biology - consortium-based approach to disease
  • Trafficking to cell surface - "minimal export threshold" embracing key fundamental properties of protein fold-folding kinetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Balch, W. E., Braakman, I., Brodsky, J., Frizzell, R., Guggino, W., Lukacs, G. L., Penland, C., Pollard, H., Skach, W., Sorscher, E., & Thomas, P. (2010). Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease. In Protein Misfolding Diseases: Current and Emerging Principles and Therapies (pp. 425-452). John Wiley and Sons. https://doi.org/10.1002/9780470572702.ch19