Foetal and childhood growth and asthma in adult life

David J P Barker, Clive Osmond, Tom J. Forsén, Kent Thornburg, Eero Kajantie, Johan G. Eriksson

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Aim Recent research suggests that asthma may originate through defects in the airway epithelium, acquired in utero, and an altered response to infections after birth. Here, we examine whether asthma in adult life is associated with reduced body size at birth and poor living conditions in childhood. Methods We studied 658 people taking medication for asthma in a cohort of 13 345 men and women born in Helsinki, Finland, during 1934-1944. Their body and placental size at birth, and their living conditions and growth in childhood, had been recorded. Results The odds ratios for asthma were 0.93 (95% CI 0.89-0.97, p = 0.001) per cm increase in birth length and 0.92 (0.89-0.96, p <0.001) per cm increase in the length of placental surface. After allowing for size at birth, growth during childhood was unrelated to asthma. People who were born into families of low socio-economic status were at increased risk of later asthma. Conclusion Slow linear growth in utero, which could be a result of impaired placentation, increases the risk of later asthma. Slow linear growth may be associated with impaired development of the airways. Babies with impaired lung development born into families of low socio-economic status may be most vulnerable to the disease.

    Original languageEnglish (US)
    Pages (from-to)732-738
    Number of pages7
    JournalActa Paediatrica, International Journal of Paediatrics
    Volume102
    Issue number7
    DOIs
    StatePublished - 2013

    Fingerprint

    Fetal Development
    Asthma
    Parturition
    Social Conditions
    Body Size
    Growth
    Economics
    Placentation
    Finland
    Epithelium
    Odds Ratio
    Lung
    Infection
    Research

    Keywords

    • Asthma
    • Birthweight
    • Childhood growth
    • Childhood living conditions
    • Placenta

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

    Cite this

    Barker, D. J. P., Osmond, C., Forsén, T. J., Thornburg, K., Kajantie, E., & Eriksson, J. G. (2013). Foetal and childhood growth and asthma in adult life. Acta Paediatrica, International Journal of Paediatrics, 102(7), 732-738. https://doi.org/10.1111/apa.12257

    Foetal and childhood growth and asthma in adult life. / Barker, David J P; Osmond, Clive; Forsén, Tom J.; Thornburg, Kent; Kajantie, Eero; Eriksson, Johan G.

    In: Acta Paediatrica, International Journal of Paediatrics, Vol. 102, No. 7, 2013, p. 732-738.

    Research output: Contribution to journalArticle

    Barker, DJP, Osmond, C, Forsén, TJ, Thornburg, K, Kajantie, E & Eriksson, JG 2013, 'Foetal and childhood growth and asthma in adult life', Acta Paediatrica, International Journal of Paediatrics, vol. 102, no. 7, pp. 732-738. https://doi.org/10.1111/apa.12257
    Barker, David J P ; Osmond, Clive ; Forsén, Tom J. ; Thornburg, Kent ; Kajantie, Eero ; Eriksson, Johan G. / Foetal and childhood growth and asthma in adult life. In: Acta Paediatrica, International Journal of Paediatrics. 2013 ; Vol. 102, No. 7. pp. 732-738.
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