Focus article report of the NIH task force on research standards for chronic low back pain

Richard A. Deyo, Samuel F. Dworkin, Dagmar Amtmann, Gunnar Andersson, David Borenstein, Eugene Carragee, John Carrino, Roger Chou, Karon Cook, Anthony Delitto, Christine Goertz, Partap Khalsa, John Loeser, Sean Mackey, James Panagis, James Rainville, Tor Tosteson, Dennis Turk, Michael Von Korff, Debra K. Weiner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

BACKGROUND:: Despite rapidly increasing intervention, functional disability due to chronic low back pain (cLBP) has increased in recent decades. We often cannot identify mechanisms to explain the major negative impact cLBP has on patients' lives. Such cLBP is often termed non-specific and may be due to multiple biologic and behavioral etiologies. Researchers use varied inclusion criteria, definitions, baseline assessments, and outcome measures, which impede comparisons and consensus. METHODS:: The NIH Pain Consortium therefore charged a Research Task Force (RTF) to draft standards for research on cLBP. The resulting multidisciplinary panel developed a 3-stage process, each with a 2-day meeting. RESULTS:: The panel recommended using 2 questions to define cLBP; classifying cLBP by its impact (defined by pain intensity, pain interference, and physical function); use of a minimum dataset to describe research participants (drawing heavily on the PROMIS methodology); reporting "responder analyses" in addition to mean outcome scores; and suggestions for future research and dissemination. The Pain Consortium has approved the recommendations, which investigators should incorporate into NIH grant proposals. CONCLUSIONS:: The RTF believes these recommendations will advance the field, help to resolve controversies, and facilitate future research addressing the genomic, neurologic, and other mechanistic substrates of chronic low back pain. Greater consistency in reporting should facilitate comparisons among studies and the development of phenotypes. We expect that the RTF recommendations will become a dynamic document and undergo continual improvement.

Original languageEnglish (US)
Pages (from-to)701-712
Number of pages12
JournalClinical Journal of Pain
Volume30
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • NIH Task Force
  • chronic low back pain
  • low back pain
  • minimum dataset
  • research standards

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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    Deyo, R. A., Dworkin, S. F., Amtmann, D., Andersson, G., Borenstein, D., Carragee, E., Carrino, J., Chou, R., Cook, K., Delitto, A., Goertz, C., Khalsa, P., Loeser, J., Mackey, S., Panagis, J., Rainville, J., Tosteson, T., Turk, D., Von Korff, M., & Weiner, D. K. (2014). Focus article report of the NIH task force on research standards for chronic low back pain. Clinical Journal of Pain, 30(8), 701-712. https://doi.org/10.1097/AJP.0000000000000120