Focal seizure propagation in the intracranial EEG

Sigmund Jenssen, Colin Roberts, Edward J. Gracely, Dennis J. Dlugos, Michael R. Sperling

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction: Intracranial EEG offers a unique opportunity to study epileptic seizures in humans. Seizure propagation has not been extensively studied. We aimed to compare the propagation of focal seizures with onset in different brain regions. Methods: Seven zones were defined as medial frontal (MF), dorsolateral frontal (DLF), orbitofrontal (OF), medial temporal (MF), lateral temporal (LT), parietal (P) and occipital (O). Routes and times of ipsilateral (IPT) and contralateral (CPT) propagation as well as ictal frequency in onset zone and propagation zone were compared. Results: Forty patients had 112 seizures. (Mean and median number of seizures per zone was 16 and 15). Preferred routes of propagation, based on ictal onset, were: MF to contralateral MF; DLF to ispilateral temporal lobe; OF to contralateral OF and ispilateral temporal lobe; MT to contralateral MT; LT to ispilateral MT and OF and contralateral LT and MT; P to ispilateral temporal lobe, DLF and O; O to ipsilateral MT. IPT and CPT varied markedly between zones. Ictal onset frequency was faster than propagated frequency. Conclusion: Seizure propagation varies according to onset zone possibly following major pathways. This needs confirmation. The findings could aid in the interpretation of symptoms and EEG and may result useful for future treatment using brain stimulation or disconnective surgery. The limitations are clearly stated.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalEpilepsy Research
Volume93
Issue number1
DOIs
StatePublished - Jan 2011

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Seizures
Temporal Lobe
Stroke
Brain
Electroencephalography
Epilepsy
Electrocorticography
Therapeutics

Keywords

  • Epilepsy surgery
  • Intracranial EEG
  • Neuroanatomy
  • Symptomatology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Jenssen, S., Roberts, C., Gracely, E. J., Dlugos, D. J., & Sperling, M. R. (2011). Focal seizure propagation in the intracranial EEG. Epilepsy Research, 93(1), 25-32. https://doi.org/10.1016/j.eplepsyres.2010.10.008

Focal seizure propagation in the intracranial EEG. / Jenssen, Sigmund; Roberts, Colin; Gracely, Edward J.; Dlugos, Dennis J.; Sperling, Michael R.

In: Epilepsy Research, Vol. 93, No. 1, 01.2011, p. 25-32.

Research output: Contribution to journalArticle

Jenssen, S, Roberts, C, Gracely, EJ, Dlugos, DJ & Sperling, MR 2011, 'Focal seizure propagation in the intracranial EEG', Epilepsy Research, vol. 93, no. 1, pp. 25-32. https://doi.org/10.1016/j.eplepsyres.2010.10.008
Jenssen, Sigmund ; Roberts, Colin ; Gracely, Edward J. ; Dlugos, Dennis J. ; Sperling, Michael R. / Focal seizure propagation in the intracranial EEG. In: Epilepsy Research. 2011 ; Vol. 93, No. 1. pp. 25-32.
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