Focal increased cortical density in immediate postembolization CT scan of patients with intracranial aneurysms

Arzu Ozturk, Isil Saatci, A. G. Pamuk, C. Erdogan, I. Akmangit, S. Geyik, H. S. Cekirge

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Cortical hyperdensity was observed in the immediate postembolization CT scans of some patients with intracranial aneurysms following uneventful endovascular treatments. The clinical significance and possible underlying mechanism were evaluated. MATERIAL AND METHODS: Ninety-three consecutive patients with a total of 100 intracranial aneurysms, treated by endosaccular packing, were studied. Seventy-four aneurysms were treated with balloon assistance, and the remaining aneurysms were treated without balloon assistance. All patients underwent cranial CT just before and immediately after the endovascular treatment. If the posttreatment CT showed any new finding, an immediate MR imaging and a repeat CT 4-6 hours after the initial posttreatment CT were performed. Several parameters were investigated related to the presence of cortical hyperdensity. RESULTS: Cranial CT showed focal cortical hyperdensity following the treatment of 40/74 aneurysms (54%) with balloon remodeling and 9/26 aneurysms (34.6%) without balloon assistance. None of these patients were symptomatic, and cortical hyperdensity resolved in the repeat CT scans. A statistically significant relationship was observed between the presence of this finding and the total amount of contrast material, microcatheter time, number of balloon inflations, and total balloon inflation time. CONCLUSION: Immediate postembolization CT may show focal cortical hyperdensity following uneventful endovascular aneurysm treatment, most likely caused by blood-brain barrier disruption resulting in accumulation of contrast medium. The hyperdensity was more frequent when balloon assistance was used but was also seen in the patients with no balloon use. It is important to differentiate this clinically insignificant finding from possible hemorrhage, which would affect patients' immediate postprocedural medical management.

Original languageEnglish (US)
Pages (from-to)1866-1875
Number of pages10
JournalAmerican Journal of Neuroradiology
Volume27
Issue number9
StatePublished - Oct 2006
Externally publishedYes

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Intracranial Aneurysm
Aneurysm
Economic Inflation
Contrast Media
Therapeutics
Blood-Brain Barrier
Hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ozturk, A., Saatci, I., Pamuk, A. G., Erdogan, C., Akmangit, I., Geyik, S., & Cekirge, H. S. (2006). Focal increased cortical density in immediate postembolization CT scan of patients with intracranial aneurysms. American Journal of Neuroradiology, 27(9), 1866-1875.

Focal increased cortical density in immediate postembolization CT scan of patients with intracranial aneurysms. / Ozturk, Arzu; Saatci, Isil; Pamuk, A. G.; Erdogan, C.; Akmangit, I.; Geyik, S.; Cekirge, H. S.

In: American Journal of Neuroradiology, Vol. 27, No. 9, 10.2006, p. 1866-1875.

Research output: Contribution to journalArticle

Ozturk, A, Saatci, I, Pamuk, AG, Erdogan, C, Akmangit, I, Geyik, S & Cekirge, HS 2006, 'Focal increased cortical density in immediate postembolization CT scan of patients with intracranial aneurysms', American Journal of Neuroradiology, vol. 27, no. 9, pp. 1866-1875.
Ozturk A, Saatci I, Pamuk AG, Erdogan C, Akmangit I, Geyik S et al. Focal increased cortical density in immediate postembolization CT scan of patients with intracranial aneurysms. American Journal of Neuroradiology. 2006 Oct;27(9):1866-1875.
Ozturk, Arzu ; Saatci, Isil ; Pamuk, A. G. ; Erdogan, C. ; Akmangit, I. ; Geyik, S. ; Cekirge, H. S. / Focal increased cortical density in immediate postembolization CT scan of patients with intracranial aneurysms. In: American Journal of Neuroradiology. 2006 ; Vol. 27, No. 9. pp. 1866-1875.
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abstract = "BACKGROUND AND PURPOSE: Cortical hyperdensity was observed in the immediate postembolization CT scans of some patients with intracranial aneurysms following uneventful endovascular treatments. The clinical significance and possible underlying mechanism were evaluated. MATERIAL AND METHODS: Ninety-three consecutive patients with a total of 100 intracranial aneurysms, treated by endosaccular packing, were studied. Seventy-four aneurysms were treated with balloon assistance, and the remaining aneurysms were treated without balloon assistance. All patients underwent cranial CT just before and immediately after the endovascular treatment. If the posttreatment CT showed any new finding, an immediate MR imaging and a repeat CT 4-6 hours after the initial posttreatment CT were performed. Several parameters were investigated related to the presence of cortical hyperdensity. RESULTS: Cranial CT showed focal cortical hyperdensity following the treatment of 40/74 aneurysms (54{\%}) with balloon remodeling and 9/26 aneurysms (34.6{\%}) without balloon assistance. None of these patients were symptomatic, and cortical hyperdensity resolved in the repeat CT scans. A statistically significant relationship was observed between the presence of this finding and the total amount of contrast material, microcatheter time, number of balloon inflations, and total balloon inflation time. CONCLUSION: Immediate postembolization CT may show focal cortical hyperdensity following uneventful endovascular aneurysm treatment, most likely caused by blood-brain barrier disruption resulting in accumulation of contrast medium. The hyperdensity was more frequent when balloon assistance was used but was also seen in the patients with no balloon use. It is important to differentiate this clinically insignificant finding from possible hemorrhage, which would affect patients' immediate postprocedural medical management.",
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