Focal cortical dysplasia is more common in boys than in girls

Xilma R. Ortiz-González, Annapurna Poduri, Colin Roberts, Joseph E. Sullivan, Eric D. Marsh, Brenda E. Porter

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Genetics and environment likely contribute to the development of medically intractable epilepsy; however, in most patients the specific combination of etiologies remains unknown. Here, we undertook a multicenter retrospective cohort study of sex distribution in pediatric patients undergoing epilepsy surgery and carried out a secondary analysis of the same population subdivided by histopathologic diagnosis. In the multicenter cohort of patients with intractable epilepsy undergoing surgery regardless of etiology (n. = 206), 63% were boys, which is significantly more boys than expected for the general population (Fisher exact two-tailed p. = 0.017). Subgroup analysis found that of the 90 patients with a histopathologic diagnosis of focal cortical dysplasia, 72% were boys, giving an odds ratio (OR) of 2.5 (95% CI, 1.34 to 4.62) for male sex. None of the other etiologies had a male sex predominance. Future studies could examine the biological relevance and potential genetic and pathophysiological mechanisms of this observation.

Original languageEnglish (US)
Pages (from-to)121-123
Number of pages3
JournalEpilepsy and Behavior
Volume27
Issue number1
DOIs
StatePublished - Apr 2013

Fingerprint

Malformations of Cortical Development
Sex Distribution
Population
Epilepsy
Cohort Studies
Retrospective Studies
Odds Ratio
Pediatrics
Drug Resistant Epilepsy

Keywords

  • Epilepsy surgery
  • Focal cortical dysplasia
  • Gender
  • Pediatric epilepsy
  • Sex

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Ortiz-González, X. R., Poduri, A., Roberts, C., Sullivan, J. E., Marsh, E. D., & Porter, B. E. (2013). Focal cortical dysplasia is more common in boys than in girls. Epilepsy and Behavior, 27(1), 121-123. https://doi.org/10.1016/j.yebeh.2012.12.035

Focal cortical dysplasia is more common in boys than in girls. / Ortiz-González, Xilma R.; Poduri, Annapurna; Roberts, Colin; Sullivan, Joseph E.; Marsh, Eric D.; Porter, Brenda E.

In: Epilepsy and Behavior, Vol. 27, No. 1, 04.2013, p. 121-123.

Research output: Contribution to journalArticle

Ortiz-González, XR, Poduri, A, Roberts, C, Sullivan, JE, Marsh, ED & Porter, BE 2013, 'Focal cortical dysplasia is more common in boys than in girls', Epilepsy and Behavior, vol. 27, no. 1, pp. 121-123. https://doi.org/10.1016/j.yebeh.2012.12.035
Ortiz-González XR, Poduri A, Roberts C, Sullivan JE, Marsh ED, Porter BE. Focal cortical dysplasia is more common in boys than in girls. Epilepsy and Behavior. 2013 Apr;27(1):121-123. https://doi.org/10.1016/j.yebeh.2012.12.035
Ortiz-González, Xilma R. ; Poduri, Annapurna ; Roberts, Colin ; Sullivan, Joseph E. ; Marsh, Eric D. ; Porter, Brenda E. / Focal cortical dysplasia is more common in boys than in girls. In: Epilepsy and Behavior. 2013 ; Vol. 27, No. 1. pp. 121-123.
@article{1b6646821593430e8b9d116625460419,
title = "Focal cortical dysplasia is more common in boys than in girls",
abstract = "Genetics and environment likely contribute to the development of medically intractable epilepsy; however, in most patients the specific combination of etiologies remains unknown. Here, we undertook a multicenter retrospective cohort study of sex distribution in pediatric patients undergoing epilepsy surgery and carried out a secondary analysis of the same population subdivided by histopathologic diagnosis. In the multicenter cohort of patients with intractable epilepsy undergoing surgery regardless of etiology (n. = 206), 63{\%} were boys, which is significantly more boys than expected for the general population (Fisher exact two-tailed p. = 0.017). Subgroup analysis found that of the 90 patients with a histopathologic diagnosis of focal cortical dysplasia, 72{\%} were boys, giving an odds ratio (OR) of 2.5 (95{\%} CI, 1.34 to 4.62) for male sex. None of the other etiologies had a male sex predominance. Future studies could examine the biological relevance and potential genetic and pathophysiological mechanisms of this observation.",
keywords = "Epilepsy surgery, Focal cortical dysplasia, Gender, Pediatric epilepsy, Sex",
author = "Ortiz-Gonz{\'a}lez, {Xilma R.} and Annapurna Poduri and Colin Roberts and Sullivan, {Joseph E.} and Marsh, {Eric D.} and Porter, {Brenda E.}",
year = "2013",
month = "4",
doi = "10.1016/j.yebeh.2012.12.035",
language = "English (US)",
volume = "27",
pages = "121--123",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Focal cortical dysplasia is more common in boys than in girls

AU - Ortiz-González, Xilma R.

AU - Poduri, Annapurna

AU - Roberts, Colin

AU - Sullivan, Joseph E.

AU - Marsh, Eric D.

AU - Porter, Brenda E.

PY - 2013/4

Y1 - 2013/4

N2 - Genetics and environment likely contribute to the development of medically intractable epilepsy; however, in most patients the specific combination of etiologies remains unknown. Here, we undertook a multicenter retrospective cohort study of sex distribution in pediatric patients undergoing epilepsy surgery and carried out a secondary analysis of the same population subdivided by histopathologic diagnosis. In the multicenter cohort of patients with intractable epilepsy undergoing surgery regardless of etiology (n. = 206), 63% were boys, which is significantly more boys than expected for the general population (Fisher exact two-tailed p. = 0.017). Subgroup analysis found that of the 90 patients with a histopathologic diagnosis of focal cortical dysplasia, 72% were boys, giving an odds ratio (OR) of 2.5 (95% CI, 1.34 to 4.62) for male sex. None of the other etiologies had a male sex predominance. Future studies could examine the biological relevance and potential genetic and pathophysiological mechanisms of this observation.

AB - Genetics and environment likely contribute to the development of medically intractable epilepsy; however, in most patients the specific combination of etiologies remains unknown. Here, we undertook a multicenter retrospective cohort study of sex distribution in pediatric patients undergoing epilepsy surgery and carried out a secondary analysis of the same population subdivided by histopathologic diagnosis. In the multicenter cohort of patients with intractable epilepsy undergoing surgery regardless of etiology (n. = 206), 63% were boys, which is significantly more boys than expected for the general population (Fisher exact two-tailed p. = 0.017). Subgroup analysis found that of the 90 patients with a histopathologic diagnosis of focal cortical dysplasia, 72% were boys, giving an odds ratio (OR) of 2.5 (95% CI, 1.34 to 4.62) for male sex. None of the other etiologies had a male sex predominance. Future studies could examine the biological relevance and potential genetic and pathophysiological mechanisms of this observation.

KW - Epilepsy surgery

KW - Focal cortical dysplasia

KW - Gender

KW - Pediatric epilepsy

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=84873937171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873937171&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2012.12.035

DO - 10.1016/j.yebeh.2012.12.035

M3 - Article

C2 - 23416281

AN - SCOPUS:84873937171

VL - 27

SP - 121

EP - 123

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 1

ER -