Focal cortical dysplasia is more common in boys than in girls

Xilma R. Ortiz-González, Annapurna Poduri, Colin M. Roberts, Joseph E. Sullivan, Eric D. Marsh, Brenda E. Porter

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Genetics and environment likely contribute to the development of medically intractable epilepsy; however, in most patients the specific combination of etiologies remains unknown. Here, we undertook a multicenter retrospective cohort study of sex distribution in pediatric patients undergoing epilepsy surgery and carried out a secondary analysis of the same population subdivided by histopathologic diagnosis. In the multicenter cohort of patients with intractable epilepsy undergoing surgery regardless of etiology (n. = 206), 63% were boys, which is significantly more boys than expected for the general population (Fisher exact two-tailed p. = 0.017). Subgroup analysis found that of the 90 patients with a histopathologic diagnosis of focal cortical dysplasia, 72% were boys, giving an odds ratio (OR) of 2.5 (95% CI, 1.34 to 4.62) for male sex. None of the other etiologies had a male sex predominance. Future studies could examine the biological relevance and potential genetic and pathophysiological mechanisms of this observation.

Original languageEnglish (US)
Pages (from-to)121-123
Number of pages3
JournalEpilepsy and Behavior
Volume27
Issue number1
DOIs
StatePublished - Apr 2013

Keywords

  • Epilepsy surgery
  • Focal cortical dysplasia
  • Gender
  • Pediatric epilepsy
  • Sex

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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    Ortiz-González, X. R., Poduri, A., Roberts, C. M., Sullivan, J. E., Marsh, E. D., & Porter, B. E. (2013). Focal cortical dysplasia is more common in boys than in girls. Epilepsy and Behavior, 27(1), 121-123. https://doi.org/10.1016/j.yebeh.2012.12.035