TY - JOUR
T1 - FNA diagnosis of giant cell fibroblastoma
T2 - A case report of an unusual pediatric soft tissue tumor
AU - Davis, Jessica L.
AU - Mathes, Erin
AU - Berry, Anna B.
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Giant cell fibroblastoma (GCF) is a rare pediatric soft tissue tumor, which exists on a spectrum with dermatofibrosarcoma protuberans (DFSP). Histologic features are well established for these entities; however, cytologic findings have not been well characterized. We report for the first time a case of GCF, confirmed by cytogenetics, with mixed DFSP features. In this case of an 8-month-old boy, a fine needle aspiration specimen showed a low-grade spindle cell tumor, with oval to spindled cells dispersed singly and in patternless groups, and with occasional giant cells. Subsequent histologic features were consistent with GCF, which is an uncommon, CD34 positive, soft tissue neoplasm with a distinct molecular aberration. This case emphasizes the differential diagnosis in pediatric soft tissue tumors and stresses the unique features of GCF.
AB - Giant cell fibroblastoma (GCF) is a rare pediatric soft tissue tumor, which exists on a spectrum with dermatofibrosarcoma protuberans (DFSP). Histologic features are well established for these entities; however, cytologic findings have not been well characterized. We report for the first time a case of GCF, confirmed by cytogenetics, with mixed DFSP features. In this case of an 8-month-old boy, a fine needle aspiration specimen showed a low-grade spindle cell tumor, with oval to spindled cells dispersed singly and in patternless groups, and with occasional giant cells. Subsequent histologic features were consistent with GCF, which is an uncommon, CD34 positive, soft tissue neoplasm with a distinct molecular aberration. This case emphasizes the differential diagnosis in pediatric soft tissue tumors and stresses the unique features of GCF.
KW - dermatofibrosarcoma protuberans (DFSP)
KW - fine needle aspiration (FNA)
KW - giant cell fibroblastoma (GCF)
KW - pediatric
KW - soft tissue
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U2 - 10.1002/dc.23201
DO - 10.1002/dc.23201
M3 - Article
C2 - 25088682
AN - SCOPUS:84925037462
SN - 8755-1039
VL - 43
SP - 325
EP - 328
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
IS - 4
ER -