FNA diagnosis of giant cell fibroblastoma

A case report of an unusual pediatric soft tissue tumor

Jessica Davis, Erin Mathes, Anna B. Berry

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Giant cell fibroblastoma (GCF) is a rare pediatric soft tissue tumor, which exists on a spectrum with dermatofibrosarcoma protuberans (DFSP). Histologic features are well established for these entities; however, cytologic findings have not been well characterized. We report for the first time a case of GCF, confirmed by cytogenetics, with mixed DFSP features. In this case of an 8-month-old boy, a fine needle aspiration specimen showed a low-grade spindle cell tumor, with oval to spindled cells dispersed singly and in patternless groups, and with occasional giant cells. Subsequent histologic features were consistent with GCF, which is an uncommon, CD34 positive, soft tissue neoplasm with a distinct molecular aberration. This case emphasizes the differential diagnosis in pediatric soft tissue tumors and stresses the unique features of GCF.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalDiagnostic Cytopathology
Volume43
Issue number4
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Dermatofibrosarcoma
Pediatrics
Neoplasms
Soft Tissue Neoplasms
Giant Cells
Fine Needle Biopsy
Cytogenetics
Differential Diagnosis

Keywords

  • dermatofibrosarcoma protuberans (DFSP)
  • fine needle aspiration (FNA)
  • giant cell fibroblastoma (GCF)
  • pediatric
  • soft tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

FNA diagnosis of giant cell fibroblastoma : A case report of an unusual pediatric soft tissue tumor. / Davis, Jessica; Mathes, Erin; Berry, Anna B.

In: Diagnostic Cytopathology, Vol. 43, No. 4, 01.01.2015, p. 325-328.

Research output: Contribution to journalArticle

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