Abstract
Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% greater than can be accounted for by the parent fluphenazine alone, and varied widely between patients. A sigmoidal relationship between total neuroleptic activity of plasma and response was found, with a continued plateau of response at higher total neuroleptic levels. Furthermore, the RBA data suggested (P<0.002) that two populations of drug-responsive schizophrenics exist which may be discriminated by the total D2 binding activity of plasma required for response.
Original language | English (US) |
---|---|
Pages (from-to) | 270-273 |
Number of pages | 4 |
Journal | Psychopharmacology |
Volume | 90 |
Issue number | 2 |
DOIs | |
State | Published - Sep 1986 |
Externally published | Yes |
Keywords
- Antipsychotic drug
- Drug level-response
- Drug response
- Fluphenazine
- Gas chromatography
- Radioreceptor binding assay
- Schizophrenia
ASJC Scopus subject areas
- Pharmacology