TY - JOUR
T1 - Fluoride related changes in behavioral outcomes may relate to increased serotonin
AU - Lu, Fuxin
AU - Zhang, Yan
AU - Trivedi, Alpa
AU - Jiang, Xianging
AU - Chandra, Dave
AU - Zheng, Jiaolin
AU - Nakano, Yukiko
AU - Abduweli Uyghurturk, Dawud
AU - Jalai, Rozita
AU - Onur, Sirin Guner
AU - Mentes, Ali
AU - DenBesten, Pamela K.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Fluoride ingestion has been linked to changes in behavior in mice and rats, related to dose, sex of the animal, and the timing of exposure. Previous studies have shown the behavior of female rats to be most affected by postnatal fluoride exposure, and in this study we determined the effects of postnatal fluoride exposure on anxiety related behavior and serotonin. Mice given 50 ppm fluoride in drinking water had increased entries in the open arms of the elevated plus maze, suggesting reduced anxiety. Both peripheral and central serotonin was increased in the fluoride treated mice. In a cohort of children drinking water containing 2.5 ppm fluoride, serum serotonin was also increased as compared to controls. The mechanisms by which fluoride results in an increase peripheral and central serotonin are not well understood, but warrant further study, as these effects may also be relevant to prenatal fluoride related changes in behavior in both mice and humans.
AB - Fluoride ingestion has been linked to changes in behavior in mice and rats, related to dose, sex of the animal, and the timing of exposure. Previous studies have shown the behavior of female rats to be most affected by postnatal fluoride exposure, and in this study we determined the effects of postnatal fluoride exposure on anxiety related behavior and serotonin. Mice given 50 ppm fluoride in drinking water had increased entries in the open arms of the elevated plus maze, suggesting reduced anxiety. Both peripheral and central serotonin was increased in the fluoride treated mice. In a cohort of children drinking water containing 2.5 ppm fluoride, serum serotonin was also increased as compared to controls. The mechanisms by which fluoride results in an increase peripheral and central serotonin are not well understood, but warrant further study, as these effects may also be relevant to prenatal fluoride related changes in behavior in both mice and humans.
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U2 - 10.1016/j.physbeh.2019.02.017
DO - 10.1016/j.physbeh.2019.02.017
M3 - Article
C2 - 30904570
AN - SCOPUS:85063425132
SN - 0031-9384
VL - 206
SP - 76
EP - 83
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -