Fluoride kinetics and renal function during enflurane anaesthesia

Per-Olof Järnberg, J. Ekstrand, L. Irestedt, J. Santesson

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Renal function, fluoride formation and excretion were studied during and after enflurane anesthesia in seven patients. During anesthesia, urine flow rate, inulin clearance, PAH clearance and fractional sodium excretion were 13, 78, 65 and 49% of control values, respectively. Renal function was promptly restored postoperatively. Enflurane was metabolized to inorganic fluoride with a mean maximal serum level of 17.4 ± 3.3 μM. Fractional fluoride excretion decreased during anesthesia to 35% of the control value. Postoperatively, there was a highly significant correlation between the increase in fractional fluoride excretion and the rise in urinary pH during two consecutive 3-hour periods. It is suggested that tubular reabsorption of fluoride is inversely related to tubular fluid pH and that fluoride is reabsorbed by non-ionic diffusion.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalActa Anaesthesiologica Scandinavica
Issue numberSuppl 71
Publication statusPublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Järnberg, P-O., Ekstrand, J., Irestedt, L., & Santesson, J. (1979). Fluoride kinetics and renal function during enflurane anaesthesia. Acta Anaesthesiologica Scandinavica, 23(Suppl 71), 20-23.